Syntheses of 2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one: A precursor of a bioactive electrophile from Gramineae

Carlos A. Escobar, Michael Kluge, Dieter Sicker

Resultado de la investigación: Contribución a una revistaArtículo

9 Citas (Scopus)

Resumen

2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one (8), the hitherto undescribed free hemiacetatic aglycone of a benzoxazinoid acetal glucoside naturally occurring in wheat, has been synthesized following two pathways, independently. This cyclic hydroxamic acid methyl ester proved to be very unstable when in solution. This gives rise to the assumption that HDIBOA naturally released from its acetal glucoside is by methoxide elimination a precursor to form a multi-centered electrophile that was recently reported to be the bioactive principle of the benzoxazinoid lead.

Idioma originalInglés
Páginas (desde-hasta)1017-1020
Número de páginas4
PublicaciónTetrahedron Letters
Volumen38
N.º6
DOI
EstadoPublicada - 10 feb 1997

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Descubrimiento de medicamentos
  • Química orgánica

Huella Profundice en los temas de investigación de 'Syntheses of 2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one: A precursor of a bioactive electrophile from Gramineae'. En conjunto forman una huella única.

  • Citar esto