Resumen
2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one (8), the hitherto undescribed free hemiacetatic aglycone of a benzoxazinoid acetal glucoside naturally occurring in wheat, has been synthesized following two pathways, independently. This cyclic hydroxamic acid methyl ester proved to be very unstable when in solution. This gives rise to the assumption that HDIBOA naturally released from its acetal glucoside is by methoxide elimination a precursor to form a multi-centered electrophile that was recently reported to be the bioactive principle of the benzoxazinoid lead.
| Idioma original | Inglés |
|---|---|
| Páginas (desde-hasta) | 1017-1020 |
| Número de páginas | 4 |
| Publicación | Tetrahedron Letters |
| Volumen | 38 |
| N.º | 6 |
| DOI | |
| Estado | Publicada - 10 feb 1997 |
Áreas temáticas de ASJC Scopus
- Bioquímica
- Descubrimiento de medicamentos
- Química orgánica
Huella Profundice en los temas de investigación de 'Syntheses of 2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one: A precursor of a bioactive electrophile from Gramineae'. En conjunto forman una huella única.
Citar esto
Escobar, C. A., Kluge, M., & Sicker, D. (1997). Syntheses of 2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one: A precursor of a bioactive electrophile from Gramineae. Tetrahedron Letters, 38(6), 1017-1020. https://doi.org/10.1016/S0040-4039(96)02492-6