Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain

Hugo F. Miranda, Margarita M. Puig, Juan Carlos Prieto, Gianni Pinardi

Resultado de la investigación: Article

112 Citas (Scopus)

Resumen

The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice (writhing test). The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID. By isobolographic analysis, this ED50 was compared to the theoretical additive ED50 calculated from the ED50 of paracetamol and of each NSAID alone obtained from ED 50 dose-response curves. As shown by isobolographic analysis, all the combinations were synergistic, the experimental ED50s being significantly smaller than the theoretically calculated ED50s. The results of this study demonstrate potent interactions between paracetamol and NSAIDs and validate the clinical use of combinations of these drugs in the treatment of pain conditions.

Idioma originalEnglish
Páginas (desde-hasta)22-28
Número de páginas7
PublicaciónPain
Volumen121
N.º1-2
DOI
EstadoPublished - 1 mar 2006

Huella dactilar

Acute Pain
Acetaminophen
Anti-Inflammatory Agents
meloxicam
nimesulide
Pharmaceutical Preparations
Dipyrone
Piroxicam
Ketoprofen
Naproxen
Diclofenac
Ibuprofen
Drug Combinations
Constriction
Acetic Acid
Pain
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Citar esto

Miranda, Hugo F. ; Puig, Margarita M. ; Prieto, Juan Carlos ; Pinardi, Gianni. / Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. En: Pain. 2006 ; Vol. 121, N.º 1-2. pp. 22-28.
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abstract = "The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice (writhing test). The effective dose that produced 50{\%} antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID. By isobolographic analysis, this ED50 was compared to the theoretical additive ED50 calculated from the ED50 of paracetamol and of each NSAID alone obtained from ED 50 dose-response curves. As shown by isobolographic analysis, all the combinations were synergistic, the experimental ED50s being significantly smaller than the theoretically calculated ED50s. The results of this study demonstrate potent interactions between paracetamol and NSAIDs and validate the clinical use of combinations of these drugs in the treatment of pain conditions.",
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Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. / Miranda, Hugo F.; Puig, Margarita M.; Prieto, Juan Carlos; Pinardi, Gianni.

En: Pain, Vol. 121, N.º 1-2, 01.03.2006, p. 22-28.

Resultado de la investigación: Article

TY - JOUR

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AU - Prieto, Juan Carlos

AU - Pinardi, Gianni

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