Resumen
The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice (writhing test). The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID. By isobolographic analysis, this ED50 was compared to the theoretical additive ED50 calculated from the ED50 of paracetamol and of each NSAID alone obtained from ED 50 dose-response curves. As shown by isobolographic analysis, all the combinations were synergistic, the experimental ED50s being significantly smaller than the theoretically calculated ED50s. The results of this study demonstrate potent interactions between paracetamol and NSAIDs and validate the clinical use of combinations of these drugs in the treatment of pain conditions.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 22-28 |
| Número de páginas | 7 |
| Publicación | Pain |
| Volumen | 121 |
| N.º | 1-2 |
| DOI | |
| Estado | Published - 1 mar 2006 |
Huella dactilar
ASJC Scopus subject areas
- Pharmacology
- Neurology
- Clinical Neurology
- Anesthesiology and Pain Medicine
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Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. / Miranda, Hugo F.; Puig, Margarita M.; Prieto, Juan Carlos; Pinardi, Gianni.
En: Pain, Vol. 121, N.º 1-2, 01.03.2006, p. 22-28.Resultado de la investigación: Article
TY - JOUR
T1 - Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain
AU - Miranda, Hugo F.
AU - Puig, Margarita M.
AU - Prieto, Juan Carlos
AU - Pinardi, Gianni
PY - 2006/3/1
Y1 - 2006/3/1
N2 - The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice (writhing test). The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID. By isobolographic analysis, this ED50 was compared to the theoretical additive ED50 calculated from the ED50 of paracetamol and of each NSAID alone obtained from ED 50 dose-response curves. As shown by isobolographic analysis, all the combinations were synergistic, the experimental ED50s being significantly smaller than the theoretically calculated ED50s. The results of this study demonstrate potent interactions between paracetamol and NSAIDs and validate the clinical use of combinations of these drugs in the treatment of pain conditions.
AB - The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice (writhing test). The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID. By isobolographic analysis, this ED50 was compared to the theoretical additive ED50 calculated from the ED50 of paracetamol and of each NSAID alone obtained from ED 50 dose-response curves. As shown by isobolographic analysis, all the combinations were synergistic, the experimental ED50s being significantly smaller than the theoretically calculated ED50s. The results of this study demonstrate potent interactions between paracetamol and NSAIDs and validate the clinical use of combinations of these drugs in the treatment of pain conditions.
KW - Abdominal constriction test
KW - Antinociception
KW - Isobologram
KW - NSAIDs
KW - Paracetamol
KW - Synergy
KW - Writhing test
UR - http://www.scopus.com/inward/record.url?scp=32944464344&partnerID=8YFLogxK
U2 - 10.1016/j.pain.2005.11.012
DO - 10.1016/j.pain.2005.11.012
M3 - Article
C2 - 16480830
AN - SCOPUS:32944464344
VL - 121
SP - 22
EP - 28
JO - Pain
JF - Pain
SN - 0304-3959
IS - 1-2
ER -