Synergism between fentanyl and tramadol in tonic inflammatory pain: The orofacial formalin test

Hugo F. Miranda, Viviana Noriega, Ramiro J. Zepeda, Fernando Sierralta, Juan C. Prieto

Resultado de la investigación: Article

7 Citas (Scopus)

Resumen

Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97±0.32 mg/kg for phase I and 1.79±0.30 mg/kg for phase II and 0.062±0.0040 mg/kg in phase I and 0.041±0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.

Idioma originalEnglish
Páginas (desde-hasta)1132-1137
Número de páginas6
PublicaciónInflammation
Volumen35
N.º3
DOI
EstadoPublished - 1 jun 2012

Huella dactilar

Tramadol
Facial Pain
Fentanyl
Pain Measurement
Opioid Analgesics
Time Management
Trigeminal Nerve
Nociception
Formaldehyde
Pharmacology
Pain
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Citar esto

Miranda, H. F., Noriega, V., Zepeda, R. J., Sierralta, F., & Prieto, J. C. (2012). Synergism between fentanyl and tramadol in tonic inflammatory pain: The orofacial formalin test. Inflammation, 35(3), 1132-1137. https://doi.org/10.1007/s10753-011-9420-7
Miranda, Hugo F. ; Noriega, Viviana ; Zepeda, Ramiro J. ; Sierralta, Fernando ; Prieto, Juan C. / Synergism between fentanyl and tramadol in tonic inflammatory pain : The orofacial formalin test. En: Inflammation. 2012 ; Vol. 35, N.º 3. pp. 1132-1137.
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Miranda, HF, Noriega, V, Zepeda, RJ, Sierralta, F & Prieto, JC 2012, 'Synergism between fentanyl and tramadol in tonic inflammatory pain: The orofacial formalin test', Inflammation, vol. 35, n.º 3, pp. 1132-1137. https://doi.org/10.1007/s10753-011-9420-7

Synergism between fentanyl and tramadol in tonic inflammatory pain : The orofacial formalin test. / Miranda, Hugo F.; Noriega, Viviana; Zepeda, Ramiro J.; Sierralta, Fernando; Prieto, Juan C.

En: Inflammation, Vol. 35, N.º 3, 01.06.2012, p. 1132-1137.

Resultado de la investigación: Article

TY - JOUR

T1 - Synergism between fentanyl and tramadol in tonic inflammatory pain

T2 - The orofacial formalin test

AU - Miranda, Hugo F.

AU - Noriega, Viviana

AU - Zepeda, Ramiro J.

AU - Sierralta, Fernando

AU - Prieto, Juan C.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97±0.32 mg/kg for phase I and 1.79±0.30 mg/kg for phase II and 0.062±0.0040 mg/kg in phase I and 0.041±0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.

AB - Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97±0.32 mg/kg for phase I and 1.79±0.30 mg/kg for phase II and 0.062±0.0040 mg/kg in phase I and 0.041±0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.

KW - Isobolographic analysis, synergism, orofacial formalin test

KW - Opioids

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