Synergism between COX-3 inhibitors in two animal models of pain

J. Muñoz, C. Navarro, V. Noriega, G. Pinardi, F. Sierralta, J. C. Prieto, H. F. Miranda

Resultado de la investigación: Article

19 Citas (Scopus)

Resumen

Objective and design: The antinociception induced by the intraperitoneal coadministration in mice of combinations of metamizol and paracetamol was evaluated in the tail flick test and orofacial formalin test. Methods: The antinociception of each drugs alone and the interaction of the combinations was evaluated by isobolographic analysis in the tail-flick and in the formalin orofacial assay of mice. Results: Mice pretreated with the drugs demonstrated that the antinociception of metamizol and paracetamol is dose-dependent. The potency range on the antinocifensive responses for metamizol or paracetamol was as follows: orofacial (Phase II) > orofacial (Phase I) > tail flick. In addition, the coadministration of metamizol with paracetamol induced a strong synergistic antinociception in the algesiometer assays. Both drugs showed effectiveness in inflammatory pain. Conclusion: These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.

Idioma originalEnglish
Páginas (desde-hasta)65-71
Número de páginas7
PublicaciónInflammopharmacology
Volumen18
N.º2
DOI
EstadoPublished - 1 abr 2010

Huella dactilar

Dipyrone
Acetaminophen
Animal Models
Pain
Tail
Pharmaceutical Preparations
Pain Measurement
Drug Interactions
Formaldehyde
Analgesics
Protein Isoforms
Pharmacology

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

Citar esto

Muñoz, J., Navarro, C., Noriega, V., Pinardi, G., Sierralta, F., Prieto, J. C., & Miranda, H. F. (2010). Synergism between COX-3 inhibitors in two animal models of pain. Inflammopharmacology, 18(2), 65-71. https://doi.org/10.1007/s10787-009-0019-7
Muñoz, J. ; Navarro, C. ; Noriega, V. ; Pinardi, G. ; Sierralta, F. ; Prieto, J. C. ; Miranda, H. F. / Synergism between COX-3 inhibitors in two animal models of pain. En: Inflammopharmacology. 2010 ; Vol. 18, N.º 2. pp. 65-71.
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Muñoz, J, Navarro, C, Noriega, V, Pinardi, G, Sierralta, F, Prieto, JC & Miranda, HF 2010, 'Synergism between COX-3 inhibitors in two animal models of pain', Inflammopharmacology, vol. 18, n.º 2, pp. 65-71. https://doi.org/10.1007/s10787-009-0019-7

Synergism between COX-3 inhibitors in two animal models of pain. / Muñoz, J.; Navarro, C.; Noriega, V.; Pinardi, G.; Sierralta, F.; Prieto, J. C.; Miranda, H. F.

En: Inflammopharmacology, Vol. 18, N.º 2, 01.04.2010, p. 65-71.

Resultado de la investigación: Article

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T1 - Synergism between COX-3 inhibitors in two animal models of pain

AU - Muñoz, J.

AU - Navarro, C.

AU - Noriega, V.

AU - Pinardi, G.

AU - Sierralta, F.

AU - Prieto, J. C.

AU - Miranda, H. F.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Objective and design: The antinociception induced by the intraperitoneal coadministration in mice of combinations of metamizol and paracetamol was evaluated in the tail flick test and orofacial formalin test. Methods: The antinociception of each drugs alone and the interaction of the combinations was evaluated by isobolographic analysis in the tail-flick and in the formalin orofacial assay of mice. Results: Mice pretreated with the drugs demonstrated that the antinociception of metamizol and paracetamol is dose-dependent. The potency range on the antinocifensive responses for metamizol or paracetamol was as follows: orofacial (Phase II) > orofacial (Phase I) > tail flick. In addition, the coadministration of metamizol with paracetamol induced a strong synergistic antinociception in the algesiometer assays. Both drugs showed effectiveness in inflammatory pain. Conclusion: These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.

AB - Objective and design: The antinociception induced by the intraperitoneal coadministration in mice of combinations of metamizol and paracetamol was evaluated in the tail flick test and orofacial formalin test. Methods: The antinociception of each drugs alone and the interaction of the combinations was evaluated by isobolographic analysis in the tail-flick and in the formalin orofacial assay of mice. Results: Mice pretreated with the drugs demonstrated that the antinociception of metamizol and paracetamol is dose-dependent. The potency range on the antinocifensive responses for metamizol or paracetamol was as follows: orofacial (Phase II) > orofacial (Phase I) > tail flick. In addition, the coadministration of metamizol with paracetamol induced a strong synergistic antinociception in the algesiometer assays. Both drugs showed effectiveness in inflammatory pain. Conclusion: These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.

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Muñoz J, Navarro C, Noriega V, Pinardi G, Sierralta F, Prieto JC y otros. Synergism between COX-3 inhibitors in two animal models of pain. Inflammopharmacology. 2010 abr 1;18(2):65-71. https://doi.org/10.1007/s10787-009-0019-7