Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells

Daniela A. Geraldo, Esteban F. Duran-Lara, Daniel Aguayo, Raul E. Cachau, Jaime Tapia, Rodrigo Esparza, Miguel J. Yacaman, Fernando Danilo Gonzalez-Nilo, Leonardo S. Santos

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

32 Citas (Scopus)

Resumen

Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.

Idioma originalInglés
Páginas (desde-hasta)483-492
Número de páginas10
PublicaciónAnalytical and Bioanalytical Chemistry
Volumen400
N.º2
DOI
EstadoPublicada - abr 2011

Áreas temáticas de ASJC Scopus

  • Química analítica
  • Bioquímica

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