Substituted bidentate and ancillary ligands modulate the bioimaging properties of the classical Re(i) tricarbonyl core with yeasts and bacteria

Resultado de la investigación: Article

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Resumen

Rhenium(i) tricarbonyl complexes with heteroaromatic ligands have been intensely investigated with respect to their properties as imaging probes, although they have only recently been tested in vivo. In this context, fac-Re(CO)3(N,N)L complexes (N,N: substituted bidentate ligand; L: ancillary ligand) are the most studied complexes due to their photophysical properties. However, the role of the N,N bidentate ligand in classical fac-Re(CO)3(N,N)L complexes (i.e. where L is a halogen such as Br) has not been explored regarding cytotoxicity and staining capabilities in walled cells (i.e. yeasts and bacteria). In the present study, we tested different rhenium(i) tricarbonyl complexes of type fac-Re(CO)3(N,N)Br [where N,N are 1,10-phenanthroline (phen) (C1); 5,6-dione-1,10-phenanthroline (dione) (C2); 2,2′-bpy (bpy) (C3); 4,4′-dimethyl-2,2′-bpy (dmb) (C4); and 4,4′-diethanoate-2,2′-bpy (deeb) (C5)] in order to characterize the properties of the N,N bidentate ligand in cellular biomarkers. We also compared these classical rhenium(i) tricarbonyl complexes (C1 to C5) with a fac-Re(CO)3(deeb)L+ complex, where L is the Schiff base (E)-2-((3-amino-pyridin-4-ylimino)-methyl)-4,6-di-tert-butylphenol, with respect to its potential for cell labelling. In our study, we found that both the N,N substituted bidentate ligand and the ancillary ligand L contributed to modulating the suitability in cell bioimaging, showing that it is possible to perform molecular engineering design to obtain improved biomarkers for walled cells, and eventually for other cell types.

IdiomaEnglish
Páginas2140-2147
Número de páginas8
PublicaciónNew Journal of Chemistry
Volumen41
Número de edición5
DOI
EstadoPublished - 1 ene 2017

Huella dactilar

Yeast
Bacteria
Ligands
Carbon Monoxide
Rhenium
Biomarkers
Halogens
Schiff Bases
Cytotoxicity
Labeling
Imaging techniques

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

Citar esto

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title = "Substituted bidentate and ancillary ligands modulate the bioimaging properties of the classical Re(i) tricarbonyl core with yeasts and bacteria",
abstract = "Rhenium(i) tricarbonyl complexes with heteroaromatic ligands have been intensely investigated with respect to their properties as imaging probes, although they have only recently been tested in vivo. In this context, fac-Re(CO)3(N,N)L complexes (N,N: substituted bidentate ligand; L: ancillary ligand) are the most studied complexes due to their photophysical properties. However, the role of the N,N bidentate ligand in classical fac-Re(CO)3(N,N)L complexes (i.e. where L is a halogen such as Br) has not been explored regarding cytotoxicity and staining capabilities in walled cells (i.e. yeasts and bacteria). In the present study, we tested different rhenium(i) tricarbonyl complexes of type fac-Re(CO)3(N,N)Br [where N,N are 1,10-phenanthroline (phen) (C1); 5,6-dione-1,10-phenanthroline (dione) (C2); 2,2′-bpy (bpy) (C3); 4,4′-dimethyl-2,2′-bpy (dmb) (C4); and 4,4′-diethanoate-2,2′-bpy (deeb) (C5)] in order to characterize the properties of the N,N bidentate ligand in cellular biomarkers. We also compared these classical rhenium(i) tricarbonyl complexes (C1 to C5) with a fac-Re(CO)3(deeb)L+ complex, where L is the Schiff base (E)-2-((3-amino-pyridin-4-ylimino)-methyl)-4,6-di-tert-butylphenol, with respect to its potential for cell labelling. In our study, we found that both the N,N substituted bidentate ligand and the ancillary ligand L contributed to modulating the suitability in cell bioimaging, showing that it is possible to perform molecular engineering design to obtain improved biomarkers for walled cells, and eventually for other cell types.",
author = "Alexander Carre{\~n}o and Aros, {Alejandra E.} and Carolina Otero and Rub{\'e}n Polanco and Manuel Gacit{\'u}a and Ramiro Arratia-P{\'e}rez and Fuentes, {Juan A.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1039/c6nj03792e",
language = "English",
volume = "41",
pages = "2140--2147",
journal = "New Journal of Chemistry",
issn = "1144-0546",
publisher = "Royal Society of Chemistry",
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TY - JOUR

T1 - Substituted bidentate and ancillary ligands modulate the bioimaging properties of the classical Re(i) tricarbonyl core with yeasts and bacteria

AU - Carreño,Alexander

AU - Aros,Alejandra E.

AU - Otero,Carolina

AU - Polanco,Rubén

AU - Gacitúa,Manuel

AU - Arratia-Pérez,Ramiro

AU - Fuentes,Juan A.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Rhenium(i) tricarbonyl complexes with heteroaromatic ligands have been intensely investigated with respect to their properties as imaging probes, although they have only recently been tested in vivo. In this context, fac-Re(CO)3(N,N)L complexes (N,N: substituted bidentate ligand; L: ancillary ligand) are the most studied complexes due to their photophysical properties. However, the role of the N,N bidentate ligand in classical fac-Re(CO)3(N,N)L complexes (i.e. where L is a halogen such as Br) has not been explored regarding cytotoxicity and staining capabilities in walled cells (i.e. yeasts and bacteria). In the present study, we tested different rhenium(i) tricarbonyl complexes of type fac-Re(CO)3(N,N)Br [where N,N are 1,10-phenanthroline (phen) (C1); 5,6-dione-1,10-phenanthroline (dione) (C2); 2,2′-bpy (bpy) (C3); 4,4′-dimethyl-2,2′-bpy (dmb) (C4); and 4,4′-diethanoate-2,2′-bpy (deeb) (C5)] in order to characterize the properties of the N,N bidentate ligand in cellular biomarkers. We also compared these classical rhenium(i) tricarbonyl complexes (C1 to C5) with a fac-Re(CO)3(deeb)L+ complex, where L is the Schiff base (E)-2-((3-amino-pyridin-4-ylimino)-methyl)-4,6-di-tert-butylphenol, with respect to its potential for cell labelling. In our study, we found that both the N,N substituted bidentate ligand and the ancillary ligand L contributed to modulating the suitability in cell bioimaging, showing that it is possible to perform molecular engineering design to obtain improved biomarkers for walled cells, and eventually for other cell types.

AB - Rhenium(i) tricarbonyl complexes with heteroaromatic ligands have been intensely investigated with respect to their properties as imaging probes, although they have only recently been tested in vivo. In this context, fac-Re(CO)3(N,N)L complexes (N,N: substituted bidentate ligand; L: ancillary ligand) are the most studied complexes due to their photophysical properties. However, the role of the N,N bidentate ligand in classical fac-Re(CO)3(N,N)L complexes (i.e. where L is a halogen such as Br) has not been explored regarding cytotoxicity and staining capabilities in walled cells (i.e. yeasts and bacteria). In the present study, we tested different rhenium(i) tricarbonyl complexes of type fac-Re(CO)3(N,N)Br [where N,N are 1,10-phenanthroline (phen) (C1); 5,6-dione-1,10-phenanthroline (dione) (C2); 2,2′-bpy (bpy) (C3); 4,4′-dimethyl-2,2′-bpy (dmb) (C4); and 4,4′-diethanoate-2,2′-bpy (deeb) (C5)] in order to characterize the properties of the N,N bidentate ligand in cellular biomarkers. We also compared these classical rhenium(i) tricarbonyl complexes (C1 to C5) with a fac-Re(CO)3(deeb)L+ complex, where L is the Schiff base (E)-2-((3-amino-pyridin-4-ylimino)-methyl)-4,6-di-tert-butylphenol, with respect to its potential for cell labelling. In our study, we found that both the N,N substituted bidentate ligand and the ancillary ligand L contributed to modulating the suitability in cell bioimaging, showing that it is possible to perform molecular engineering design to obtain improved biomarkers for walled cells, and eventually for other cell types.

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U2 - 10.1039/c6nj03792e

DO - 10.1039/c6nj03792e

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JO - New Journal of Chemistry

T2 - New Journal of Chemistry

JF - New Journal of Chemistry

SN - 1144-0546

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