Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines

Ivan Montenegro, Giacomo Tomasoni, Claudia Bosio, Natalia Quiñones, Alejandro Madrid, Hector Carrasco, Andres Olea, Rolando Martinez, Mauricio Cuellar, Joan Villena

Resultado de la investigación: Article

13 Citas (Scopus)

Resumen

Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.

Idioma originalEnglish
Páginas (desde-hasta)18993-19006
Número de páginas14
PublicaciónMolecules
Volumen19
N.º11
DOI
EstadoPublished - 1 nov 2014

Huella dactilar

multiple docking adapters
Sesquiterpenes
cultured cells
permeability
cancer
Cells
membranes
Cell Line
Mitochondrial Membranes
cells
Inhibitory Concentration 50
Permeability
Neoplasms
Derivatives
Membranes
polygodial
drimane
confertifolin
drimenol
In Vitro Techniques

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Citar esto

Montenegro, I., Tomasoni, G., Bosio, C., Quiñones, N., Madrid, A., Carrasco, H., ... Villena, J. (2014). Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines. Molecules, 19(11), 18993-19006. https://doi.org/10.3390/molecules191118993
Montenegro, Ivan ; Tomasoni, Giacomo ; Bosio, Claudia ; Quiñones, Natalia ; Madrid, Alejandro ; Carrasco, Hector ; Olea, Andres ; Martinez, Rolando ; Cuellar, Mauricio ; Villena, Joan. / Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines. En: Molecules. 2014 ; Vol. 19, N.º 11. pp. 18993-19006.
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title = "Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines",
abstract = "Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 {\`i}M of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.",
keywords = "Apoptosis, Cancer cell lines, Caspasa-3 activity, Cytotoxic activity, Drimanes, Mitochondrial membrane permeability, Nordrimanes, Sesquiterpenes",
author = "Ivan Montenegro and Giacomo Tomasoni and Claudia Bosio and Natalia Qui{\~n}ones and Alejandro Madrid and Hector Carrasco and Andres Olea and Rolando Martinez and Mauricio Cuellar and Joan Villena",
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Montenegro, I, Tomasoni, G, Bosio, C, Quiñones, N, Madrid, A, Carrasco, H, Olea, A, Martinez, R, Cuellar, M & Villena, J 2014, 'Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines', Molecules, vol. 19, n.º 11, pp. 18993-19006. https://doi.org/10.3390/molecules191118993

Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines. / Montenegro, Ivan; Tomasoni, Giacomo; Bosio, Claudia; Quiñones, Natalia; Madrid, Alejandro; Carrasco, Hector; Olea, Andres; Martinez, Rolando; Cuellar, Mauricio; Villena, Joan.

En: Molecules, Vol. 19, N.º 11, 01.11.2014, p. 18993-19006.

Resultado de la investigación: Article

TY - JOUR

T1 - Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines

AU - Montenegro, Ivan

AU - Tomasoni, Giacomo

AU - Bosio, Claudia

AU - Quiñones, Natalia

AU - Madrid, Alejandro

AU - Carrasco, Hector

AU - Olea, Andres

AU - Martinez, Rolando

AU - Cuellar, Mauricio

AU - Villena, Joan

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.

AB - Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.

KW - Apoptosis

KW - Cancer cell lines

KW - Caspasa-3 activity

KW - Cytotoxic activity

KW - Drimanes

KW - Mitochondrial membrane permeability

KW - Nordrimanes

KW - Sesquiterpenes

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U2 - 10.3390/molecules191118993

DO - 10.3390/molecules191118993

M3 - Article

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VL - 19

SP - 18993

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JO - Molecules

JF - Molecules

SN - 1420-3049

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Montenegro I, Tomasoni G, Bosio C, Quiñones N, Madrid A, Carrasco H y otros. Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines. Molecules. 2014 nov 1;19(11):18993-19006. https://doi.org/10.3390/molecules191118993