TY - JOUR
T1 - Structure, conformation and biological activity studies on rivularin, a new heliangolide isolated from Leptocarpha rivularis
AU - Martinez, Rolando
AU - Kesternich, Victor
AU - Carrasco, Hector
AU - Bustos, Carlos
AU - Fernandez, Silvia
PY - 1998
Y1 - 1998
N2 - Rivularin, a new heliangolide, was isolated together with leptocarpin as a minor constituent from Leptocarpha rivularis. Structural and conformational studies of this compound were based on elemental analysis. IR spectroscopy, 13C-NMR and 1H-NMR experiments (LIS, NOESY and Py-d5 spectra). Of the four most probable conformations for rivularin, the preferred one is the TC conformation. The 1H-NMR data were compared with those obtained from the synthetic β-epimer 11,13-dihydroleptocarpin, prepared by either catalytic hydrogenation or sodium borohydride reduction of leptocarpin, in order to establish the correct structure and conformation in the heliangolide.
AB - Rivularin, a new heliangolide, was isolated together with leptocarpin as a minor constituent from Leptocarpha rivularis. Structural and conformational studies of this compound were based on elemental analysis. IR spectroscopy, 13C-NMR and 1H-NMR experiments (LIS, NOESY and Py-d5 spectra). Of the four most probable conformations for rivularin, the preferred one is the TC conformation. The 1H-NMR data were compared with those obtained from the synthetic β-epimer 11,13-dihydroleptocarpin, prepared by either catalytic hydrogenation or sodium borohydride reduction of leptocarpin, in order to establish the correct structure and conformation in the heliangolide.
KW - Biological activity H-NMR studies
KW - Conformational analysis
KW - Rivularine
KW - Sesquiterpene lactones
UR - http://www.scopus.com/inward/record.url?scp=0009600958&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0009600958
VL - 43
SP - 7
EP - 12
JO - Journal of the Chilean Chemical Society
JF - Journal of the Chilean Chemical Society
SN - 0717-9324
IS - 1
ER -