Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum

Brenda Modak, M. Leonor Contreras, Fernando González-Nilo, René Torres

Resultado de la investigación: Contribución a una revistaArtículo

44 Citas (Scopus)

Resumen

Relationships between the structural characteristics of flavonoids isolated from the resinous exudate of Heliotropium sinuatum and their antioxidant activity were studied. Relationships between the structural characteristics of flavonoids isolated from the resinous exudate of Heliotropium sinuatum and their antioxidant activity were studied. Radical formation energies, ΔH of dehydrogenation and spin densities were calculated using DFT methods (B3LYP/6-31G*). Results show that studied flavonoids can be divided into two sets according to their activity. It has been found that antioxidant activity depends both on substitution pattern of hydroxyl groups of the flavonoid skeleton and the presence of an unsaturation at the C2-C3 bond. A good tendency between ΔH of dehydrogenation and antioxidant activity was established.

Idioma originalInglés
Páginas (desde-hasta)309-312
Número de páginas4
PublicaciónBioorganic and Medicinal Chemistry Letters
Volumen15
N.º2
DOI
EstadoPublicada - 17 ene 2005

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Medicina molecular
  • Biología molecular
  • Ciencias farmacéuticas
  • Descubrimiento de medicamentos
  • Bioquímica clínica
  • Química orgánica

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