Structural antitumoral activity relationships of synthetic chalcones

Cesar Echeverria, Juan Francisco Santibañez, Oscar Donoso-Tauda, Carlos A. Escobar, Rodrigo Ramirez-Tagle

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

117 Citas (Scopus)

Resumen

Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.

Idioma originalInglés
Páginas (desde-hasta)221-231
Número de páginas11
PublicaciónInternational Journal of Molecular Sciences
Volumen10
N.º1
DOI
EstadoPublicada - ene 2009

Áreas temáticas de ASJC Scopus

  • Catálisis
  • Biología molecular
  • Espectroscopia
  • Informática aplicada
  • Química física y teórica
  • Química orgánica
  • Química inorgánica

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