Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome

Edward Rojas, Valmore Bermúdez, Yasaman Motlaghzadeh, Justin Mathew, Enzamaria Fidilio, Judith Faria, Joselyn Rojas, Mayela Cabrera de Bravo, Julio Contreras, Linda Pamela Mantilla, Lissé Angarita, Paola Amar Sepúlveda, Isaac Kuzmar

Resultado de la investigación: Review article

3 Citas (Scopus)

Resumen

Purpose of Review: Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease. Recent Findings: Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro. Summary: Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health.

Idioma originalEnglish
Páginas (desde-hasta)161-170
Número de páginas10
PublicaciónCurrent Nutrition Reports
Volumen7
N.º3
DOI
EstadoPublished - 1 sep 2018

Huella dactilar

Stevia
Stevia rebaudiana
metabolic syndrome
atherosclerosis
human diseases
human health
Atherosclerosis
obesity
inflammation
artificial sweeteners
Inflammation
Sweetening Agents
Bacteroides
sweeteners
Clostridium
DNA replication
intestinal microorganisms
energy content
carcinogenesis
beverages

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Citar esto

Rojas, Edward ; Bermúdez, Valmore ; Motlaghzadeh, Yasaman ; Mathew, Justin ; Fidilio, Enzamaria ; Faria, Judith ; Rojas, Joselyn ; de Bravo, Mayela Cabrera ; Contreras, Julio ; Mantilla, Linda Pamela ; Angarita, Lissé ; Sepúlveda, Paola Amar ; Kuzmar, Isaac. / Stevia rebaudiana Bertoni and Its Effects in Human Disease : Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome. En: Current Nutrition Reports. 2018 ; Vol. 7, N.º 3. pp. 161-170.
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title = "Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome",
abstract = "Purpose of Review: Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease. Recent Findings: Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro. Summary: Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health.",
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Rojas, E, Bermúdez, V, Motlaghzadeh, Y, Mathew, J, Fidilio, E, Faria, J, Rojas, J, de Bravo, MC, Contreras, J, Mantilla, LP, Angarita, L, Sepúlveda, PA & Kuzmar, I 2018, 'Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome', Current Nutrition Reports, vol. 7, n.º 3, pp. 161-170. https://doi.org/10.1007/s13668-018-0228-z

Stevia rebaudiana Bertoni and Its Effects in Human Disease : Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome. / Rojas, Edward; Bermúdez, Valmore; Motlaghzadeh, Yasaman; Mathew, Justin; Fidilio, Enzamaria; Faria, Judith; Rojas, Joselyn; de Bravo, Mayela Cabrera; Contreras, Julio; Mantilla, Linda Pamela; Angarita, Lissé; Sepúlveda, Paola Amar; Kuzmar, Isaac.

En: Current Nutrition Reports, Vol. 7, N.º 3, 01.09.2018, p. 161-170.

Resultado de la investigación: Review article

TY - JOUR

T1 - Stevia rebaudiana Bertoni and Its Effects in Human Disease

T2 - Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome

AU - Rojas, Edward

AU - Bermúdez, Valmore

AU - Motlaghzadeh, Yasaman

AU - Mathew, Justin

AU - Fidilio, Enzamaria

AU - Faria, Judith

AU - Rojas, Joselyn

AU - de Bravo, Mayela Cabrera

AU - Contreras, Julio

AU - Mantilla, Linda Pamela

AU - Angarita, Lissé

AU - Sepúlveda, Paola Amar

AU - Kuzmar, Isaac

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Purpose of Review: Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease. Recent Findings: Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro. Summary: Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health.

AB - Purpose of Review: Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease. Recent Findings: Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro. Summary: Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health.

KW - Hypertension

KW - Obesity

KW - Stevia rebaudiana Bertoni

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85057637933&partnerID=8YFLogxK

U2 - 10.1007/s13668-018-0228-z

DO - 10.1007/s13668-018-0228-z

M3 - Review article

AN - SCOPUS:85057637933

VL - 7

SP - 161

EP - 170

JO - Current Nutrition Reports

JF - Current Nutrition Reports

SN - 2161-3311

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