Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease

Anika Geelhaar, Verena Moos, Katina Schinnerling, Kristina Allers, Christoph Loddenkemper, Florence Fenollar, Bernard LaScola, Didier Raoult, Thomas Schneider

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

14 Citas (Scopus)

Resumen

Whipple's disease is a chronic multisystemic infection caused by Tropheryma whipplei that is characterized by arthritis, weight loss, and diarrhea. The immunological defects in the duodenal mucosa, the site of major replication of the agent underlying the pathogenesis of Whipple's disease, are poorly understood. Mucosal immunoglobulins are essential for the defense against intestinal pathogens; therefore, we analyzed the B-cell response in duodenal specimens and sera of Whipple's disease patients. Whereas systemic immunoglobulin production was affected only marginally, duodenal biopsy specimens of Whipple's disease patients contained reduced numbers of immunoglobulin-positive plasma cells and secreted less immunoglobulin compared to healthy controls but showed a weak secretory IgA response toward T. whipplei. This T. whipplei-specific intestinal immune response was not observed in controls. Thus, we were able to demonstrate that general mucosal immunoglobulin production in Whipple's disease patients is impaired. However, this deficiency does not completely abolish T. whipplei-specific secretory IgA production that nonetheless does not protect from chronic infection.

Idioma originalInglés
Páginas (desde-hasta)4589-4592
Número de páginas4
PublicaciónInfection and Immunity
Volumen78
N.º11
DOI
EstadoPublicada - nov 2010
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Parasitología
  • Microbiología
  • Inmunología
  • Enfermedades infecciosas

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