Solubility and kinetic release studies of naproxen and ibuprofen in soluble epichlorohydrin-β-cyclodextrin polymer

Rudy Martin, Iliana Sánchez, Roberto Cao, Jacques Rieumont

Resultado de la investigación: Article

21 Citas (Scopus)

Resumen

Naproxen (NAP) and ibuprofen (IBU) are poor water soluble anti-inflammatory drugs. A water-soluble epichlorohydrin-β-cyclodextrin polymer (β-CDEPI) was synthesized in a highly basic aqueous solution and at a molar ratio β-CD/EPI of 1:12. Drug solubility and kinetic release of NAP and IBU from the inclusion complexes they form with β-CDEPI as host was studied. Water solubility for both drugs in the presence of this polymer increased (NAP 0.28mmol and IBU 0.40mmol per gram of β-CDEPI). The apparent inclusion constants for both drugs in β-CDEPI were calculated from the solubility-phase diagrams with Kincl values of 4300±100L. mol-1 for NAP and 5100±300L.mol-1 for IBU. Kinetic release of Ibuprofen gave a pure Fick trend (t1/2) behavior. However, for Naproxen a zero order was obtained (t). These results indicate that the nature and bulkiness of the drugs are ruling these kinetic behaviors in the environment of a highly branched polymer.

Idioma originalEnglish
Páginas (desde-hasta)627-631
Número de páginas5
PublicaciónSupramolecular Chemistry
Volumen18
N.º8
DOI
EstadoPublished - dic 2006

Huella dactilar

Naproxen
Ibuprofen
Solubility
Kinetics
Pharmaceutical Preparations
Water
Polymers
Phase diagrams
Anti-Inflammatory Agents
cyclodextrin-epichlorohydrin polymer

ASJC Scopus subject areas

  • Chemistry(all)

Citar esto

Martin, Rudy ; Sánchez, Iliana ; Cao, Roberto ; Rieumont, Jacques. / Solubility and kinetic release studies of naproxen and ibuprofen in soluble epichlorohydrin-β-cyclodextrin polymer. En: Supramolecular Chemistry. 2006 ; Vol. 18, N.º 8. pp. 627-631.
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Solubility and kinetic release studies of naproxen and ibuprofen in soluble epichlorohydrin-β-cyclodextrin polymer. / Martin, Rudy; Sánchez, Iliana; Cao, Roberto; Rieumont, Jacques.

En: Supramolecular Chemistry, Vol. 18, N.º 8, 12.2006, p. 627-631.

Resultado de la investigación: Article

TY - JOUR

T1 - Solubility and kinetic release studies of naproxen and ibuprofen in soluble epichlorohydrin-β-cyclodextrin polymer

AU - Martin, Rudy

AU - Sánchez, Iliana

AU - Cao, Roberto

AU - Rieumont, Jacques

PY - 2006/12

Y1 - 2006/12

N2 - Naproxen (NAP) and ibuprofen (IBU) are poor water soluble anti-inflammatory drugs. A water-soluble epichlorohydrin-β-cyclodextrin polymer (β-CDEPI) was synthesized in a highly basic aqueous solution and at a molar ratio β-CD/EPI of 1:12. Drug solubility and kinetic release of NAP and IBU from the inclusion complexes they form with β-CDEPI as host was studied. Water solubility for both drugs in the presence of this polymer increased (NAP 0.28mmol and IBU 0.40mmol per gram of β-CDEPI). The apparent inclusion constants for both drugs in β-CDEPI were calculated from the solubility-phase diagrams with Kincl values of 4300±100L. mol-1 for NAP and 5100±300L.mol-1 for IBU. Kinetic release of Ibuprofen gave a pure Fick trend (t1/2) behavior. However, for Naproxen a zero order was obtained (t). These results indicate that the nature and bulkiness of the drugs are ruling these kinetic behaviors in the environment of a highly branched polymer.

AB - Naproxen (NAP) and ibuprofen (IBU) are poor water soluble anti-inflammatory drugs. A water-soluble epichlorohydrin-β-cyclodextrin polymer (β-CDEPI) was synthesized in a highly basic aqueous solution and at a molar ratio β-CD/EPI of 1:12. Drug solubility and kinetic release of NAP and IBU from the inclusion complexes they form with β-CDEPI as host was studied. Water solubility for both drugs in the presence of this polymer increased (NAP 0.28mmol and IBU 0.40mmol per gram of β-CDEPI). The apparent inclusion constants for both drugs in β-CDEPI were calculated from the solubility-phase diagrams with Kincl values of 4300±100L. mol-1 for NAP and 5100±300L.mol-1 for IBU. Kinetic release of Ibuprofen gave a pure Fick trend (t1/2) behavior. However, for Naproxen a zero order was obtained (t). These results indicate that the nature and bulkiness of the drugs are ruling these kinetic behaviors in the environment of a highly branched polymer.

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KW - Drug delivery

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KW - Inclusion complex

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