Solitary intraosseous neurofibroma of the mandible. Apropos of a case

Javiera Deichler, René Martínez, Sven Niklander, Heraldo Seguel, Maureen Marshall, Alfredo Esguep

Resultado de la investigación: Review article

10 Citas (Scopus)

Resumen

Neurofibroma is a benign neoplasm derived from peripheral nerves. Most of these are associated with Neurofibromatosis but may also occur as solitary lesions. When found on the head and neck they are generally located in the soft tissue. Intraosseous location is very rare. The following report describes a case of an intraosseous neurofibroma located in the left mandibular ramus of a 14-year-old child. The patient did not had clinical evidence of the lesion and it was found on a routine radiographic examination. Surgical excision of the lesion was scheduled and the sample was submitted to histopathological study. Representative sample cuts were studied using conventional techniques of hematoxylin-eosin and immunohistochemistry using primary antibodies anti S-100 protein, vimentin, and neuroespecific enolase. A review of clinical, radiographic, histologic and immunohistochemical features of other cases of intraosseuos neurofibromas located in the jaws together with the possible differential diagnosis of the lesion are discussed. Our case corresponds to a intraosseous neurofibroma of controveltial diagnosis because even though it presents typical neurofibroma histomorphological features it has immunophenotype different from usual.

Idioma originalEnglish
Páginas (desde-hasta)704-707
Número de páginas4
PublicaciónMedicina Oral, Patologia Oral y Cirugia Bucal
Volumen16
N.º6
DOI
EstadoPublished - sep 2011

Huella dactilar

Neurofibroma
Mandible
Peripheral Nervous System Neoplasms
Neurofibromatoses
S100 Proteins
Phosphopyruvate Hydratase
Vimentin
Hematoxylin
Eosine Yellowish-(YS)
Jaw
Anti-Idiotypic Antibodies
Differential Diagnosis
Neck
Immunohistochemistry
Head

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology
  • Surgery

Citar esto

Deichler, Javiera ; Martínez, René ; Niklander, Sven ; Seguel, Heraldo ; Marshall, Maureen ; Esguep, Alfredo. / Solitary intraosseous neurofibroma of the mandible. Apropos of a case. En: Medicina Oral, Patologia Oral y Cirugia Bucal. 2011 ; Vol. 16, N.º 6. pp. 704-707.
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Solitary intraosseous neurofibroma of the mandible. Apropos of a case. / Deichler, Javiera; Martínez, René; Niklander, Sven; Seguel, Heraldo; Marshall, Maureen; Esguep, Alfredo.

En: Medicina Oral, Patologia Oral y Cirugia Bucal, Vol. 16, N.º 6, 09.2011, p. 704-707.

Resultado de la investigación: Review article

TY - JOUR

T1 - Solitary intraosseous neurofibroma of the mandible. Apropos of a case

AU - Deichler, Javiera

AU - Martínez, René

AU - Niklander, Sven

AU - Seguel, Heraldo

AU - Marshall, Maureen

AU - Esguep, Alfredo

PY - 2011/9

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N2 - Neurofibroma is a benign neoplasm derived from peripheral nerves. Most of these are associated with Neurofibromatosis but may also occur as solitary lesions. When found on the head and neck they are generally located in the soft tissue. Intraosseous location is very rare. The following report describes a case of an intraosseous neurofibroma located in the left mandibular ramus of a 14-year-old child. The patient did not had clinical evidence of the lesion and it was found on a routine radiographic examination. Surgical excision of the lesion was scheduled and the sample was submitted to histopathological study. Representative sample cuts were studied using conventional techniques of hematoxylin-eosin and immunohistochemistry using primary antibodies anti S-100 protein, vimentin, and neuroespecific enolase. A review of clinical, radiographic, histologic and immunohistochemical features of other cases of intraosseuos neurofibromas located in the jaws together with the possible differential diagnosis of the lesion are discussed. Our case corresponds to a intraosseous neurofibroma of controveltial diagnosis because even though it presents typical neurofibroma histomorphological features it has immunophenotype different from usual.

AB - Neurofibroma is a benign neoplasm derived from peripheral nerves. Most of these are associated with Neurofibromatosis but may also occur as solitary lesions. When found on the head and neck they are generally located in the soft tissue. Intraosseous location is very rare. The following report describes a case of an intraosseous neurofibroma located in the left mandibular ramus of a 14-year-old child. The patient did not had clinical evidence of the lesion and it was found on a routine radiographic examination. Surgical excision of the lesion was scheduled and the sample was submitted to histopathological study. Representative sample cuts were studied using conventional techniques of hematoxylin-eosin and immunohistochemistry using primary antibodies anti S-100 protein, vimentin, and neuroespecific enolase. A review of clinical, radiographic, histologic and immunohistochemical features of other cases of intraosseuos neurofibromas located in the jaws together with the possible differential diagnosis of the lesion are discussed. Our case corresponds to a intraosseous neurofibroma of controveltial diagnosis because even though it presents typical neurofibroma histomorphological features it has immunophenotype different from usual.

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