Sistema de flujo continuo no segmentado con deteccion polarografica para la determinacion de ranitidina en formas farmaceuticas y orina

Pablo Jaque-Olmedo, M. Ines Toral, Pablo Richter

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

In this work we developed a method by flow injection analysis for the determination of ranitidine in pharmaceutical forms and urine, using a polarographic flow through cell as detection system which has been designed recently in our laboratory. The method is based on the reduction of the group nitro of the drug to the hydroxylamine derivative by applying a potential of -1.40 V vs mercury pool electrode. It was found a determination range of 2.38×10 -5 -1.0×10 -3 M ranitidine, with a detection limit of 7.15×10 -6 M. The relative standard deviation (n = 11) for a concentration level of 1.0×10 -4 M was 2.1%, which is comparable with the obtained, by the manual methodology. The accuracy of the method was evaluated by comparison of the results with those obtained by d.c. polarography and UV spectrophotometry and the results were quite comparable.

Idioma originalEspañol
Páginas (desde-hasta)45-53
Número de páginas9
PublicaciónBoletin de la Sociedad Chilena de Quimica
Volumen43
N.º1
EstadoPublicada - 1 dic 1998

Palabras clave

  • Continuous flow system
  • Pharmaceuticals formulations
  • Polarographic flow cell
  • Ranitidine
  • Urine

Áreas temáticas de ASJC Scopus

  • Química (todo)

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