SinEx DB: a database for single exon coding sequences in mammalian genomes

Roddy Jorquera, Rodrigo Ortiz, F. Ossandon, Juan Pablo Cárdenas, Rene Sepúlveda, Carolina González, David S. Holmes

Resultado de la investigación: Contribución a una revistaArtículo

11 Citas (Scopus)

Resumen

Eukaryotic genes are typically interrupted by intragenic, noncoding sequences termed introns. However, some genes lack introns in their coding sequence (CDS) and are generally known as 'single exon genes' (SEGs). In this work, a SEG is defined as a nuclear, protein-coding gene that lacks introns in its CDS. Whereas, many public databases of Eukaryotic multi-exon genes are available, there are only two specialized databases for SEGs. The present work addresses the need for a more extensive and diverse database by creating SinEx DB, a publicly available, searchable database of predicted SEGs from 10 completely sequenced mammalian genomes including human. SinEx DB houses the DNA and protein sequence information of these SEGs and includes their functional predictions (KOG) and the relative distribution of these functions within species. The information is stored in a relational database built with My SQL Server 5.1.33 and the complete dataset of SEG sequences and their functional predictions are available for downloading. SinEx DB can be interrogated by: (i) a browsable phylogenetic schema, (ii) carrying out BLAST searches to the in-house SinEx DB of SEGs and (iii) via an advanced search mode in which the database can be searched by key words and any combination of searches by species and predicted functions. SinEx DB provides a rich source of information for advancing our understanding of the evolution and function of SEGs.Database URL: www.sinex.cl.

Idioma originalInglés
PublicaciónDatabase : the journal of biological databases and curation
Volumen2016
DOI
EstadoPublicada - 1 ene 2016

Áreas temáticas de ASJC Scopus

  • Sistemas de información
  • Bioquímica, genética y biología molecular (todo)
  • Agricultura y biología (todo)

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    Jorquera, R., Ortiz, R., Ossandon, F., Cárdenas, J. P., Sepúlveda, R., González, C., & Holmes, D. S. (2016). SinEx DB: a database for single exon coding sequences in mammalian genomes. Database : the journal of biological databases and curation, 2016. https://doi.org/10.1093/database/baw095