Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry

M. Inés Toral, Pablo Richter, Nelson Lara, Pablo Jaque, Cesar Soto, Marcela Saavedra

Resultado de la investigación: Article

34 Citas (Scopus)

Resumen

A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets. Copyright (C) 1999 Elsevier Science B.V.

Idioma originalEnglish
Páginas (desde-hasta)67-74
Número de páginas8
PublicaciónInternational Journal of Pharmaceutics
Volumen189
N.º1
DOI
EstadoPublished - 28 oct 1999

Huella dactilar

Drug Compounding
Spectrophotometry
Chlordiazepoxide
Pharmaceutical Preparations
Calibration
Tablets
clidinium
clidinium drug combination chlordiazepoxide

ASJC Scopus subject areas

  • Pharmaceutical Science

Citar esto

Toral, M. Inés ; Richter, Pablo ; Lara, Nelson ; Jaque, Pablo ; Soto, Cesar ; Saavedra, Marcela. / Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry. En: International Journal of Pharmaceutics. 1999 ; Vol. 189, N.º 1. pp. 67-74.
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abstract = "A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets. Copyright (C) 1999 Elsevier Science B.V.",
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Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry. / Toral, M. Inés; Richter, Pablo; Lara, Nelson; Jaque, Pablo; Soto, Cesar; Saavedra, Marcela.

En: International Journal of Pharmaceutics, Vol. 189, N.º 1, 28.10.1999, p. 67-74.

Resultado de la investigación: Article

TY - JOUR

T1 - Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry

AU - Toral, M. Inés

AU - Richter, Pablo

AU - Lara, Nelson

AU - Jaque, Pablo

AU - Soto, Cesar

AU - Saavedra, Marcela

PY - 1999/10/28

Y1 - 1999/10/28

N2 - A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets. Copyright (C) 1999 Elsevier Science B.V.

AB - A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets. Copyright (C) 1999 Elsevier Science B.V.

KW - Chlordiazepoxide

KW - Clidinium bromide

KW - First derivative spectrophotometry

KW - Pharmaceutical formulations

KW - Simultaneous determination

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