Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry

M. Inés Toral, Pablo Richter, Nelson Lara, Pablo Jaque, Cesar Soto, Marcela Saavedra

Resultado de la investigación: Contribución a una revistaArtículo

36 Citas (Scopus)

Resumen

A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets. Copyright (C) 1999 Elsevier Science B.V.

Idioma originalInglés
Páginas (desde-hasta)67-74
Número de páginas8
PublicaciónInternational Journal of Pharmaceutics
Volumen189
N.º1
DOI
EstadoPublicada - 28 oct 1999

Áreas temáticas de ASJC Scopus

  • Ciencias farmacéuticas

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