Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens

H. F. Miranda; W. I. Silva; W. W. Wolstenholme; N. Cuevas

doi:10.1016/0306-3623(88)90039-0

Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens

H. F. Miranda, W. I. Silva, W. W. Wolstenholme, N. Cuevas

Facultad Medicina

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

1. 1. The effects of pirenzepine and N-methyl-scopolamine on the responses to ACh in the isolated rat vas deferens were studied. 2. 2. Pirenzepine was inactive at the M₂-ACh receptor. 3. 3. N-methyl-scopolamine was a competitive antagonist (pA₂ = 8.76) at M₂-ACh receptor, alone or in the presence of pirenzepine. 4. 4. Pirenzepine and N-methyl-scopolamine were both non-competitive antagonists at M₁-ACh receptor. 5. 5. The mixture of pirenzepine and N-methyl-scopolamine did not alter the type of antagonism demonstrated by each drug at the M₁-ACh receptor.

Idioma original	Inglés
Páginas (desde-hasta)	417-420
Número de páginas	4
Publicación	General Pharmacology
Volumen	19
N.º	3
DOI	https://doi.org/10.1016/0306-3623(88)90039-0
Estado	Publicada - 1988

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Farmacología

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10.1016/0306-3623(88)90039-0

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@article{c49b0d4529d24c5096860c861670261d,

title = "Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens",

abstract = "1. 1. The effects of pirenzepine and N-methyl-scopolamine on the responses to ACh in the isolated rat vas deferens were studied. 2. 2. Pirenzepine was inactive at the M2-ACh receptor. 3. 3. N-methyl-scopolamine was a competitive antagonist (pA2 = 8.76) at M2-ACh receptor, alone or in the presence of pirenzepine. 4. 4. Pirenzepine and N-methyl-scopolamine were both non-competitive antagonists at M1-ACh receptor. 5. 5. The mixture of pirenzepine and N-methyl-scopolamine did not alter the type of antagonism demonstrated by each drug at the M1-ACh receptor.",

author = "Miranda, {H. F.} and Silva, {W. I.} and Wolstenholme, {W. W.} and N. Cuevas",

note = "Funding Information: *This work was supported by NIH Grant 2-SO6-RR-08159-07-A1 awarded to H. F. Miranda and W. W. Wolstenholme. tAuthor to whom all correspondence should be addressed.",

year = "1988",

doi = "10.1016/0306-3623(88)90039-0",

language = "English",

volume = "19",

pages = "417--420",

journal = "General Pharmacology",

issn = "0306-3623",

publisher = "Elsevier Inc.",

number = "3",

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TY - JOUR

T1 - Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens

AU - Miranda, H. F.

AU - Silva, W. I.

AU - Wolstenholme, W. W.

AU - Cuevas, N.

N1 - Funding Information: *This work was supported by NIH Grant 2-SO6-RR-08159-07-A1 awarded to H. F. Miranda and W. W. Wolstenholme. tAuthor to whom all correspondence should be addressed.

PY - 1988

Y1 - 1988

N2 - 1. 1. The effects of pirenzepine and N-methyl-scopolamine on the responses to ACh in the isolated rat vas deferens were studied. 2. 2. Pirenzepine was inactive at the M2-ACh receptor. 3. 3. N-methyl-scopolamine was a competitive antagonist (pA2 = 8.76) at M2-ACh receptor, alone or in the presence of pirenzepine. 4. 4. Pirenzepine and N-methyl-scopolamine were both non-competitive antagonists at M1-ACh receptor. 5. 5. The mixture of pirenzepine and N-methyl-scopolamine did not alter the type of antagonism demonstrated by each drug at the M1-ACh receptor.

AB - 1. 1. The effects of pirenzepine and N-methyl-scopolamine on the responses to ACh in the isolated rat vas deferens were studied. 2. 2. Pirenzepine was inactive at the M2-ACh receptor. 3. 3. N-methyl-scopolamine was a competitive antagonist (pA2 = 8.76) at M2-ACh receptor, alone or in the presence of pirenzepine. 4. 4. Pirenzepine and N-methyl-scopolamine were both non-competitive antagonists at M1-ACh receptor. 5. 5. The mixture of pirenzepine and N-methyl-scopolamine did not alter the type of antagonism demonstrated by each drug at the M1-ACh receptor.

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U2 - 10.1016/0306-3623(88)90039-0

DO - 10.1016/0306-3623(88)90039-0

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C2 - 3417103

AN - SCOPUS:0023886434

SN - 0306-3623

VL - 19

SP - 417

EP - 420

JO - General Pharmacology

JF - General Pharmacology

IS - 3

ER -

Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens

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