Scanning electron microscopy and X-ray microanalysis of foreign bodies associated with silastic implants in humans

Arthur H. Tatum, John D. Shelburne, Peter Ingram, Dale N. Robertson, Horacio B. Croxatto, S. Diaz

Resultado de la investigación: Article

6 Citas (Scopus)

Resumen

Polydimethylsiloxane (Silastic) capsules containing megestrol acetate have been implanted in subcutaneous tissue as a method of long-term contraception. Histological studies revealed a granulomatous foreign body reaction around these capsules with birefringent crystals in multinucleated giant cells. Although several authors had interpreted these crytals as steroids, this seemed unlikely since the tissue had been processed with organic solvents. Analysis of these crystals by polarization microscopy, scanning electron microscopy, and X-ray microanalysis demonstrated that the material was talc. The talc was probably introduced as a contaminant from gloves during the implantation. Further analysis showed that capsule fragmentation could not have produced the material since Silastic particles could not be detected.

Idioma originalEnglish
Páginas (desde-hasta)543-552
Número de páginas10
PublicaciónContraception
Volumen28
N.º6
DOI
EstadoPublished - 1 ene 1983

Huella dactilar

Electron Probe Microanalysis
Foreign Bodies
Talc
Capsules
Megestrol Acetate
Polarization Microscopy
Foreign-Body Reaction
Subcutaneous Tissue
Giant Cells
Contraception
Steroids
baysilon

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Citar esto

Tatum, Arthur H. ; Shelburne, John D. ; Ingram, Peter ; Robertson, Dale N. ; Croxatto, Horacio B. ; Diaz, S. / Scanning electron microscopy and X-ray microanalysis of foreign bodies associated with silastic implants in humans. En: Contraception. 1983 ; Vol. 28, N.º 6. pp. 543-552.
@article{731f91d45f67460bb684a7f47697d44b,
title = "Scanning electron microscopy and X-ray microanalysis of foreign bodies associated with silastic implants in humans",
abstract = "Polydimethylsiloxane (Silastic) capsules containing megestrol acetate have been implanted in subcutaneous tissue as a method of long-term contraception. Histological studies revealed a granulomatous foreign body reaction around these capsules with birefringent crystals in multinucleated giant cells. Although several authors had interpreted these crytals as steroids, this seemed unlikely since the tissue had been processed with organic solvents. Analysis of these crystals by polarization microscopy, scanning electron microscopy, and X-ray microanalysis demonstrated that the material was talc. The talc was probably introduced as a contaminant from gloves during the implantation. Further analysis showed that capsule fragmentation could not have produced the material since Silastic particles could not be detected.",
author = "Tatum, {Arthur H.} and Shelburne, {John D.} and Peter Ingram and Robertson, {Dale N.} and Croxatto, {Horacio B.} and S. Diaz",
year = "1983",
month = "1",
day = "1",
doi = "10.1016/0010-7824(83)90105-1",
language = "English",
volume = "28",
pages = "543--552",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier USA",
number = "6",

}

Scanning electron microscopy and X-ray microanalysis of foreign bodies associated with silastic implants in humans. / Tatum, Arthur H.; Shelburne, John D.; Ingram, Peter; Robertson, Dale N.; Croxatto, Horacio B.; Diaz, S.

En: Contraception, Vol. 28, N.º 6, 01.01.1983, p. 543-552.

Resultado de la investigación: Article

TY - JOUR

T1 - Scanning electron microscopy and X-ray microanalysis of foreign bodies associated with silastic implants in humans

AU - Tatum, Arthur H.

AU - Shelburne, John D.

AU - Ingram, Peter

AU - Robertson, Dale N.

AU - Croxatto, Horacio B.

AU - Diaz, S.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Polydimethylsiloxane (Silastic) capsules containing megestrol acetate have been implanted in subcutaneous tissue as a method of long-term contraception. Histological studies revealed a granulomatous foreign body reaction around these capsules with birefringent crystals in multinucleated giant cells. Although several authors had interpreted these crytals as steroids, this seemed unlikely since the tissue had been processed with organic solvents. Analysis of these crystals by polarization microscopy, scanning electron microscopy, and X-ray microanalysis demonstrated that the material was talc. The talc was probably introduced as a contaminant from gloves during the implantation. Further analysis showed that capsule fragmentation could not have produced the material since Silastic particles could not be detected.

AB - Polydimethylsiloxane (Silastic) capsules containing megestrol acetate have been implanted in subcutaneous tissue as a method of long-term contraception. Histological studies revealed a granulomatous foreign body reaction around these capsules with birefringent crystals in multinucleated giant cells. Although several authors had interpreted these crytals as steroids, this seemed unlikely since the tissue had been processed with organic solvents. Analysis of these crystals by polarization microscopy, scanning electron microscopy, and X-ray microanalysis demonstrated that the material was talc. The talc was probably introduced as a contaminant from gloves during the implantation. Further analysis showed that capsule fragmentation could not have produced the material since Silastic particles could not be detected.

UR - http://www.scopus.com/inward/record.url?scp=0020971517&partnerID=8YFLogxK

U2 - 10.1016/0010-7824(83)90105-1

DO - 10.1016/0010-7824(83)90105-1

M3 - Article

VL - 28

SP - 543

EP - 552

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 6

ER -