Síndrome metabólico. Bases clínicas y fisiopatológicas para un enfoque terapéutico racional

Gonzalo Martínez R, Rodrigo Alonso K, Victoria Novik A

Resultado de la investigación: Article

2 Citas (Scopus)

Resumen

Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistance of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, that inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferator-activated receptors (PPAR) seems promising.

Idioma originalSpanish
Páginas (desde-hasta)685-694
Número de páginas10
PublicaciónRevista Medica de Chile
Volumen137
N.º5
EstadoPublished - 1 may 2009

Huella dactilar

Insulin Resistance
Peroxisome Proliferator-Activated Receptors
Angiotensins
Dyslipidemias
Aldosterone
Nonesterified Fatty Acids
Renin
Adipocytes
Adipose Tissue
Weight Loss
Smoking
Diet
Hypertension
Phenotype
Glucose
Pharmaceutical Preparations
Population
Therapeutics
Healthy Lifestyle

ASJC Scopus subject areas

  • Medicine(all)

Citar esto

Martínez R, Gonzalo ; Alonso K, Rodrigo ; Novik A, Victoria. / Síndrome metabólico. Bases clínicas y fisiopatológicas para un enfoque terapéutico racional. En: Revista Medica de Chile. 2009 ; Vol. 137, N.º 5. pp. 685-694.
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abstract = "Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20{\%} of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistance of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, that inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferator-activated receptors (PPAR) seems promising.",
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Martínez R, G, Alonso K, R & Novik A, V 2009, 'Síndrome metabólico. Bases clínicas y fisiopatológicas para un enfoque terapéutico racional', Revista Medica de Chile, vol. 137, n.º 5, pp. 685-694.

Síndrome metabólico. Bases clínicas y fisiopatológicas para un enfoque terapéutico racional. / Martínez R, Gonzalo; Alonso K, Rodrigo; Novik A, Victoria.

En: Revista Medica de Chile, Vol. 137, N.º 5, 01.05.2009, p. 685-694.

Resultado de la investigación: Article

TY - JOUR

T1 - Síndrome metabólico. Bases clínicas y fisiopatológicas para un enfoque terapéutico racional

AU - Martínez R, Gonzalo

AU - Alonso K, Rodrigo

AU - Novik A, Victoria

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistance of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, that inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferator-activated receptors (PPAR) seems promising.

AB - Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistance of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, that inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferator-activated receptors (PPAR) seems promising.

KW - Insulin resistance

KW - Metabolic Syndrome X

KW - Obesity

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