Sífilis congénita: Presentación como shock séptico después del período neonatal

Daniela Arriagada, Alejandro Donoso, Pablo Cruces, Franco Díaz

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)


Clinical spectrum of congenital syphilis ranges from asymptomatic infection to fulminant sepsis. Treponema pallidum is acquired crossing the placenta from the mother to the fetus during maternal spirochetemia or through direct contact of the child with an infected lesion at delivery. We report a 27 days-old previously healthy girl diagnosed with congenital syphilis. Her mother had an unremarkable previous history, adequate obstetric care and negative prenatal screening test for syphilis. The patient was brought to the ER due to development of skin lesions and fever in the last 24 h. She was admitted to pediatric ICU lethargic and poorly responsive, with hepatosplenomegaly and perioral, palmoplantar erythematous desquamative scaly lesions. Laboratory data revealed anemia, leukocytosis, thrombocytopenia and C-reactive protein of 183 mg/l. Soon after admission she developed septic shock with leukocytosis up to 45,800/mm3 and exacerbation of thrombocytopenia, hypoalbuminemia and metabolic acidosis. Congenital syphilis was diagnosed at the second day of admission with VDRL titers of 1:128 in serum and 1:8 in cerebrospinal fluid. Maternal serum VDRL was positive with titers of 1:32. The patient was treated with penicillin for three weeks with adequate clinical and laboratory response. Congenital syphilis is a life threating infection, but cannot always be diagnosed at birth. Health care workers must be aware of the difficulties in obtaining a definitive diagnosis and must have a high index of suspicion, considering the possible errors of prenatal serology and the diverse possible clinical presentations, including neonatal sepsis during the first month of life. Key words: Syphilis, congenital syphilis, sepsis, pediatrics.

Título traducido de la contribuciónCongenital syphilis presenting as septic shock alter the neonatal period
Idioma originalEspañol
Páginas (desde-hasta)558-563
Número de páginas6
PublicaciónRevista Chilena de Infectologia
EstadoPublicada - oct. 2012

Palabras clave

  • Congenital syphilis
  • Pediatrics
  • Sepsis
  • Syphilis

Áreas temáticas de ASJC Scopus

  • Salud pública, medioambiental y laboral
  • Enfermedades infecciosas


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