Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions

Jane B. Lian, Janet L. Stein, Gary S. Stein, André J. van Wijnen, Martin Montecino, Amjad Javed, Soraya Gutierrez, Jiali Shen, S. Kaleem Zaidi, Hicham Drissi

Resultado de la investigación: Review article

59 Citas (Scopus)

Resumen

Development of the osteoblast phenotype requires transcriptional mechanisms that regulate induction of a program of temporally expressed genes. Key components of gene activation, repression, and responsiveness to physiologic mediators require remodeling of the chromatin structure of a gene that renders promoter elements competent for the assembly of macromolecular transcriptional complexes. Here we review evidence that the Runx transcription factors support tissue-specific gene expression and bone formation by contributing to promoter structure, chromatin remodeling, and the integration of independent signaling pathways. In addition, we discuss the role of Runx2 in both activation and negative regulation of gene promoters (osteocalcin, bone sialoprotein, and Runx2/Cbfa1) in relation to the interaction of Runx with coregulatory proteins in distinct subnuclear foci. The modifications in chromatin organization and transcription of the osteocalcin gene that are influenced by the activities of Runx2/Cbfa1 mediated by interacting proteins (YAP, TLE, SMAD, C/EBP) are emphasized. These functional properties of Runx2 provide novel insights into the requirements for multiple levels of transcriptional control within the context of nuclear architecture to support the convergence of regulatory signals that control tissue-specific gene expression.

Idioma originalEnglish
Páginas (desde-hasta)141-148
Número de páginas8
PublicaciónConnective Tissue Research
Volumen44
N.ºSUPPL. 1
EstadoPublished - 2003

Huella dactilar

Chromatin Assembly and Disassembly
Transcription
Chromatin
Genes
Osteocalcin
Proteins
Gene expression
Integrin-Binding Sialoprotein
Macromolecular Substances
Gene Expression
Chemical activation
Tissue
Osteoblasts
Osteogenesis
Transcriptional Activation
Transcription Factors
Phenotype
Bone

ASJC Scopus subject areas

  • Rheumatology
  • Biochemistry
  • Orthopedics and Sports Medicine
  • Molecular Biology
  • Cell Biology

Citar esto

Lian, J. B., Stein, J. L., Stein, G. S., van Wijnen, A. J., Montecino, M., Javed, A., ... Drissi, H. (2003). Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. Connective Tissue Research, 44(SUPPL. 1), 141-148.
Lian, Jane B. ; Stein, Janet L. ; Stein, Gary S. ; van Wijnen, André J. ; Montecino, Martin ; Javed, Amjad ; Gutierrez, Soraya ; Shen, Jiali ; Zaidi, S. Kaleem ; Drissi, Hicham. / Runx2/Cbfa1 functions : Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. En: Connective Tissue Research. 2003 ; Vol. 44, N.º SUPPL. 1. pp. 141-148.
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title = "Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions",
abstract = "Development of the osteoblast phenotype requires transcriptional mechanisms that regulate induction of a program of temporally expressed genes. Key components of gene activation, repression, and responsiveness to physiologic mediators require remodeling of the chromatin structure of a gene that renders promoter elements competent for the assembly of macromolecular transcriptional complexes. Here we review evidence that the Runx transcription factors support tissue-specific gene expression and bone formation by contributing to promoter structure, chromatin remodeling, and the integration of independent signaling pathways. In addition, we discuss the role of Runx2 in both activation and negative regulation of gene promoters (osteocalcin, bone sialoprotein, and Runx2/Cbfa1) in relation to the interaction of Runx with coregulatory proteins in distinct subnuclear foci. The modifications in chromatin organization and transcription of the osteocalcin gene that are influenced by the activities of Runx2/Cbfa1 mediated by interacting proteins (YAP, TLE, SMAD, C/EBP) are emphasized. These functional properties of Runx2 provide novel insights into the requirements for multiple levels of transcriptional control within the context of nuclear architecture to support the convergence of regulatory signals that control tissue-specific gene expression.",
keywords = "Bone specific, Chromatin, Osteoblast, Osteocalcin, Runt homology domain, Runx2/Cbfa1, Transcriptional regulation",
author = "Lian, {Jane B.} and Stein, {Janet L.} and Stein, {Gary S.} and {van Wijnen}, {Andr{\'e} J.} and Martin Montecino and Amjad Javed and Soraya Gutierrez and Jiali Shen and Zaidi, {S. Kaleem} and Hicham Drissi",
year = "2003",
language = "English",
volume = "44",
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journal = "Connective Tissue Research",
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Lian, JB, Stein, JL, Stein, GS, van Wijnen, AJ, Montecino, M, Javed, A, Gutierrez, S, Shen, J, Zaidi, SK & Drissi, H 2003, 'Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions', Connective Tissue Research, vol. 44, n.º SUPPL. 1, pp. 141-148.

Runx2/Cbfa1 functions : Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. / Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; van Wijnen, André J.; Montecino, Martin; Javed, Amjad; Gutierrez, Soraya; Shen, Jiali; Zaidi, S. Kaleem; Drissi, Hicham.

En: Connective Tissue Research, Vol. 44, N.º SUPPL. 1, 2003, p. 141-148.

Resultado de la investigación: Review article

TY - JOUR

T1 - Runx2/Cbfa1 functions

T2 - Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions

AU - Lian, Jane B.

AU - Stein, Janet L.

AU - Stein, Gary S.

AU - van Wijnen, André J.

AU - Montecino, Martin

AU - Javed, Amjad

AU - Gutierrez, Soraya

AU - Shen, Jiali

AU - Zaidi, S. Kaleem

AU - Drissi, Hicham

PY - 2003

Y1 - 2003

N2 - Development of the osteoblast phenotype requires transcriptional mechanisms that regulate induction of a program of temporally expressed genes. Key components of gene activation, repression, and responsiveness to physiologic mediators require remodeling of the chromatin structure of a gene that renders promoter elements competent for the assembly of macromolecular transcriptional complexes. Here we review evidence that the Runx transcription factors support tissue-specific gene expression and bone formation by contributing to promoter structure, chromatin remodeling, and the integration of independent signaling pathways. In addition, we discuss the role of Runx2 in both activation and negative regulation of gene promoters (osteocalcin, bone sialoprotein, and Runx2/Cbfa1) in relation to the interaction of Runx with coregulatory proteins in distinct subnuclear foci. The modifications in chromatin organization and transcription of the osteocalcin gene that are influenced by the activities of Runx2/Cbfa1 mediated by interacting proteins (YAP, TLE, SMAD, C/EBP) are emphasized. These functional properties of Runx2 provide novel insights into the requirements for multiple levels of transcriptional control within the context of nuclear architecture to support the convergence of regulatory signals that control tissue-specific gene expression.

AB - Development of the osteoblast phenotype requires transcriptional mechanisms that regulate induction of a program of temporally expressed genes. Key components of gene activation, repression, and responsiveness to physiologic mediators require remodeling of the chromatin structure of a gene that renders promoter elements competent for the assembly of macromolecular transcriptional complexes. Here we review evidence that the Runx transcription factors support tissue-specific gene expression and bone formation by contributing to promoter structure, chromatin remodeling, and the integration of independent signaling pathways. In addition, we discuss the role of Runx2 in both activation and negative regulation of gene promoters (osteocalcin, bone sialoprotein, and Runx2/Cbfa1) in relation to the interaction of Runx with coregulatory proteins in distinct subnuclear foci. The modifications in chromatin organization and transcription of the osteocalcin gene that are influenced by the activities of Runx2/Cbfa1 mediated by interacting proteins (YAP, TLE, SMAD, C/EBP) are emphasized. These functional properties of Runx2 provide novel insights into the requirements for multiple levels of transcriptional control within the context of nuclear architecture to support the convergence of regulatory signals that control tissue-specific gene expression.

KW - Bone specific

KW - Chromatin

KW - Osteoblast

KW - Osteocalcin

KW - Runt homology domain

KW - Runx2/Cbfa1

KW - Transcriptional regulation

UR - http://www.scopus.com/inward/record.url?scp=12244313406&partnerID=8YFLogxK

M3 - Review article

C2 - 12952188

AN - SCOPUS:12244313406

VL - 44

SP - 141

EP - 148

JO - Connective Tissue Research

JF - Connective Tissue Research

SN - 0300-8207

IS - SUPPL. 1

ER -