Resumen
We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 4315-4329 |
| Número de páginas | 15 |
| Publicación | Oncogene |
| Volumen | 23 |
| N.º | 24 |
| DOI | |
| Estado | Published - 24 may 2004 |
Huella dactilar
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research
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Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. / Stein, Gary S.; Lian, Jane B.; Van Wijnen, Andre J.; Stein, Janet L.; Montecino, Martin; Javed, Amjad; Zaidi, Sayyed K.; Young, Daniel W.; Choi, Je Yong; Pockwinse, Shirwin M.
En: Oncogene, Vol. 23, N.º 24, 24.05.2004, p. 4315-4329.Resultado de la investigación: Review article
TY - JOUR
T1 - Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
AU - Stein, Gary S.
AU - Lian, Jane B.
AU - Van Wijnen, Andre J.
AU - Stein, Janet L.
AU - Montecino, Martin
AU - Javed, Amjad
AU - Zaidi, Sayyed K.
AU - Young, Daniel W.
AU - Choi, Je Yong
AU - Pockwinse, Shirwin M.
PY - 2004/5/24
Y1 - 2004/5/24
N2 - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.
AB - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.
KW - Chromatin modifications
KW - Gene expression
KW - Nuclear architecture
KW - Osteoblast
KW - Runx/AML/Cbfa
UR - http://www.scopus.com/inward/record.url?scp=2942548981&partnerID=8YFLogxK
U2 - 10.1038/sj.onc.1207676
DO - 10.1038/sj.onc.1207676
M3 - Review article
C2 - 15156188
AN - SCOPUS:2942548981
VL - 23
SP - 4315
EP - 4329
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 24
ER -