Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Martin Montecino, Amjad Javed, Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Shirwin M. Pockwinse

Resultado de la investigación: Review article

335 Citas (Scopus)

Resumen

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

Idioma originalEnglish
Páginas (desde-hasta)4315-4329
Número de páginas15
PublicaciónOncogene
Volumen23
N.º24
DOI
EstadoPublished - 24 may 2004

Huella dactilar

Core Binding Factor alpha Subunits
Bone Development
Nucleic Acids
Cell Differentiation
Homeostasis
Gene Expression

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Citar esto

Stein, G. S., Lian, J. B., Van Wijnen, A. J., Stein, J. L., Montecino, M., Javed, A., ... Pockwinse, S. M. (2004). Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene, 23(24), 4315-4329. https://doi.org/10.1038/sj.onc.1207676
Stein, Gary S. ; Lian, Jane B. ; Van Wijnen, Andre J. ; Stein, Janet L. ; Montecino, Martin ; Javed, Amjad ; Zaidi, Sayyed K. ; Young, Daniel W. ; Choi, Je Yong ; Pockwinse, Shirwin M. / Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. En: Oncogene. 2004 ; Vol. 23, N.º 24. pp. 4315-4329.
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abstract = "We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.",
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Stein, GS, Lian, JB, Van Wijnen, AJ, Stein, JL, Montecino, M, Javed, A, Zaidi, SK, Young, DW, Choi, JY & Pockwinse, SM 2004, 'Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression', Oncogene, vol. 23, n.º 24, pp. 4315-4329. https://doi.org/10.1038/sj.onc.1207676

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. / Stein, Gary S.; Lian, Jane B.; Van Wijnen, Andre J.; Stein, Janet L.; Montecino, Martin; Javed, Amjad; Zaidi, Sayyed K.; Young, Daniel W.; Choi, Je Yong; Pockwinse, Shirwin M.

En: Oncogene, Vol. 23, N.º 24, 24.05.2004, p. 4315-4329.

Resultado de la investigación: Review article

TY - JOUR

T1 - Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

AU - Stein, Gary S.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Stein, Janet L.

AU - Montecino, Martin

AU - Javed, Amjad

AU - Zaidi, Sayyed K.

AU - Young, Daniel W.

AU - Choi, Je Yong

AU - Pockwinse, Shirwin M.

PY - 2004/5/24

Y1 - 2004/5/24

N2 - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

AB - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

KW - Chromatin modifications

KW - Gene expression

KW - Nuclear architecture

KW - Osteoblast

KW - Runx/AML/Cbfa

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U2 - 10.1038/sj.onc.1207676

DO - 10.1038/sj.onc.1207676

M3 - Review article

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VL - 23

SP - 4315

EP - 4329

JO - Oncogene

JF - Oncogene

SN - 0950-9232

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