Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S. Stein; Jane B. Lian; Andre J. Van Wijnen; Janet L. Stein; Martin Montecino; Amjad Javed; Sayyed K. Zaidi; Daniel W. Young; Je Yong Choi; Shirwin M. Pockwinse

doi:10.1038/sj.onc.1207676

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Martin Montecino, Amjad Javed, Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Shirwin M. Pockwinse

Facultad de Ciencias de la Vida

Resultado de la investigación: Contribución a una revista › Artículo de revisión

349 Citas (Scopus)

Resumen

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

Idioma original	Inglés
Páginas (desde-hasta)	4315-4329
Número de páginas	15
Publicación	Oncogene
Volumen	23
N.º	24
DOI	https://doi.org/10.1038/sj.onc.1207676
Estado	Publicada - 24 may 2004

Áreas temáticas de ASJC Scopus

Biología molecular
Genética
Investigación sobre el cáncer

Acceder al documento

10.1038/sj.onc.1207676

Link to publication in Scopus

Huella Profundice en los temas de investigación de 'Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression'. En conjunto forman una huella única.

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Stein, G. S., Lian, J. B., Van Wijnen, A. J., Stein, J. L., Montecino, M., Javed, A., Zaidi, S. K., Young, D. W., Choi, J. Y., & Pockwinse, S. M. (2004). Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene, 23(24), 4315-4329. https://doi.org/10.1038/sj.onc.1207676

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title = "Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression",

abstract = "We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.",

keywords = "Chromatin modifications, Gene expression, Nuclear architecture, Osteoblast, Runx/AML/Cbfa",

author = "Stein, {Gary S.} and Lian, {Jane B.} and {Van Wijnen}, {Andre J.} and Stein, {Janet L.} and Martin Montecino and Amjad Javed and Zaidi, {Sayyed K.} and Young, {Daniel W.} and Choi, {Je Yong} and Pockwinse, {Shirwin M.}",

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Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. / Stein, Gary S.; Lian, Jane B.; Van Wijnen, Andre J.; Stein, Janet L.; Montecino, Martin; Javed, Amjad; Zaidi, Sayyed K.; Young, Daniel W.; Choi, Je Yong; Pockwinse, Shirwin M.

En: Oncogene, Vol. 23, N.º 24, 24.05.2004, p. 4315-4329.

Resultado de la investigación: Contribución a una revista › Artículo de revisión

TY - JOUR

T1 - Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

AU - Stein, Gary S.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Stein, Janet L.

AU - Montecino, Martin

AU - Javed, Amjad

AU - Zaidi, Sayyed K.

AU - Young, Daniel W.

AU - Choi, Je Yong

AU - Pockwinse, Shirwin M.

PY - 2004/5/24

Y1 - 2004/5/24

N2 - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

AB - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

KW - Chromatin modifications

KW - Gene expression

KW - Nuclear architecture

KW - Osteoblast

KW - Runx/AML/Cbfa

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U2 - 10.1038/sj.onc.1207676

DO - 10.1038/sj.onc.1207676

M3 - Review article

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VL - 23

SP - 4315

EP - 4329

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 24

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