Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Martin Montecino, Amjad Javed, Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Shirwin M. Pockwinse

Resultado de la investigación: Contribución a una revistaArtículo de revisión

349 Citas (Scopus)

Resumen

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

Idioma originalInglés
Páginas (desde-hasta)4315-4329
Número de páginas15
PublicaciónOncogene
Volumen23
N.º24
DOI
EstadoPublicada - 24 may 2004

Áreas temáticas de ASJC Scopus

  • Biología molecular
  • Genética
  • Investigación sobre el cáncer

Huella Profundice en los temas de investigación de 'Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression'. En conjunto forman una huella única.

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    Stein, G. S., Lian, J. B., Van Wijnen, A. J., Stein, J. L., Montecino, M., Javed, A., Zaidi, S. K., Young, D. W., Choi, J. Y., & Pockwinse, S. M. (2004). Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene, 23(24), 4315-4329. https://doi.org/10.1038/sj.onc.1207676