Role of dopamine in the physiology of T-cells and dendritic cells

Rodrigo Pacheco, Carolina E. Prado, Magaly J. Barrientos, Sebastián Bernales

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

95 Citas (Scopus)

Resumen

Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate effector cells. Because of their fundamental roles in controlling immunity, DCs and T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediate interactions into the nervous system, but can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DC and T-cell physiology and, in turn, immune response. Moreover, we discuss how alterations in the dopamine-mediated immune regulatory mechanisms could contribute to the onset of immune-related disorders.

Idioma originalInglés
Páginas (desde-hasta)8-19
Número de páginas12
PublicaciónJournal of Neuroimmunology
Volumen216
N.º1-2
DOI
EstadoPublicada - 30 nov 2009

Áreas temáticas de ASJC Scopus

  • Inmulogía y alergología
  • Inmunología
  • Neurología
  • Neurología clínica

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