Role of astroglial hemichannels and pannexons in memory and neurodegenerative diseases

Juan A. Orellana, Mauricio A. Retamal, Rodrigo Moraga-Amaro, Jimmy Stehberg

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

35 Citas (Scopus)

Resumen

Under physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseases.

Idioma originalInglés
Número de artículo26
PublicaciónFrontiers in Integrative Neuroscience
Volumen10
N.ºJULY2016
DOI
EstadoPublicada - 20 jul. 2016

Áreas temáticas de ASJC Scopus

  • Sistema sensorial
  • Neurociencia cognitiva
  • Neurociencia celular y molecular

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