Ric-8: Different cellular roles for a heterotrimeric G-protein GEF

M. V. Hinrichs, M. Torrejón, M. Montecino, J. Olate

Resultado de la investigación: Contribución a una revistaArtículo

22 Citas (Scopus)

Resumen

Signaling via heterotrimeric G-proteins is evoked by agonist-mediated stimulation of seven transmembrane spanning receptors (GPCRs). During the last decade it has become apparent that Gα subunits can be activated by receptor-independent mechanisms. Ric-8 belongs to a highly conserved protein family that regulates heterotrimeric G-protein function, acting as a non-canonical guanine nucleotide exchange factors (GEF) over a subset of Gα subunits. In this review we discuss the roles of Ric-8 in the regulation of diverse cell functions, emphasizing the contribution of its multiple domain protein structure in these diverse functions.

Idioma originalInglés
Páginas (desde-hasta)2797-2805
Número de páginas9
PublicaciónJournal of Cellular Biochemistry
Volumen113
N.º9
DOI
EstadoPublicada - sep 2012

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología celular
  • Biología molecular

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