Ric-8: Different cellular roles for a heterotrimeric G-protein GEF

M. V. Hinrichs, M. Torrejón, M. Montecino, J. Olate

Resultado de la investigación: Article

21 Citas (Scopus)

Resumen

Signaling via heterotrimeric G-proteins is evoked by agonist-mediated stimulation of seven transmembrane spanning receptors (GPCRs). During the last decade it has become apparent that Gα subunits can be activated by receptor-independent mechanisms. Ric-8 belongs to a highly conserved protein family that regulates heterotrimeric G-protein function, acting as a non-canonical guanine nucleotide exchange factors (GEF) over a subset of Gα subunits. In this review we discuss the roles of Ric-8 in the regulation of diverse cell functions, emphasizing the contribution of its multiple domain protein structure in these diverse functions.

Idioma originalEnglish
Páginas (desde-hasta)2797-2805
Número de páginas9
PublicaciónJournal of Cellular Biochemistry
Volumen113
N.º9
DOI
EstadoPublished - sep 2012

Huella dactilar

Guanine Nucleotide Exchange Factors
Heterotrimeric GTP-Binding Proteins
Proteins
Cells
Protein Domains

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Citar esto

Hinrichs, M. V. ; Torrejón, M. ; Montecino, M. ; Olate, J. / Ric-8 : Different cellular roles for a heterotrimeric G-protein GEF. En: Journal of Cellular Biochemistry. 2012 ; Vol. 113, N.º 9. pp. 2797-2805.
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Ric-8 : Different cellular roles for a heterotrimeric G-protein GEF. / Hinrichs, M. V.; Torrejón, M.; Montecino, M.; Olate, J.

En: Journal of Cellular Biochemistry, Vol. 113, N.º 9, 09.2012, p. 2797-2805.

Resultado de la investigación: Article

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AU - Olate, J.

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