Retinoic acid generates regulatory T cells in experimental transplantation

C. Moore, C. Fuentes, D. Sauma, J. Morales, M. R. Bono, M. Rosemblatt, J. A. Fierro

Resultado de la investigación: Article

3 Citas (Scopus)

Resumen

Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β and interleukin (IL) 2, generated allogeneic regulatory T cells de novo. These cells were able to inhibit skin rejection in adoptive transfer experiments. The generation of regulatory T cells ex vivo with retinoic acid, TGF-β, and IL-2 represents a new step toward specific regulation of allogeneic immune responses.

Idioma originalEnglish
Páginas (desde-hasta)2334-2337
Número de páginas4
PublicaciónTransplantation Proceedings
Volumen43
N.º6
DOI
EstadoPublished - jul 2011

Huella dactilar

Regulatory T-Lymphocytes
Tretinoin
Transplantation
Transforming Growth Factors
Interleukin-2
Adoptive Transfer
Antigen-Presenting Cells
Autoimmunity
Immunity
Lymphocytes
T-Lymphocytes
Skin

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Citar esto

Moore, C. ; Fuentes, C. ; Sauma, D. ; Morales, J. ; Bono, M. R. ; Rosemblatt, M. ; Fierro, J. A. / Retinoic acid generates regulatory T cells in experimental transplantation. En: Transplantation Proceedings. 2011 ; Vol. 43, N.º 6. pp. 2334-2337.
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Retinoic acid generates regulatory T cells in experimental transplantation. / Moore, C.; Fuentes, C.; Sauma, D.; Morales, J.; Bono, M. R.; Rosemblatt, M.; Fierro, J. A.

En: Transplantation Proceedings, Vol. 43, N.º 6, 07.2011, p. 2334-2337.

Resultado de la investigación: Article

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AU - Fierro, J. A.

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