Retinoic acid generates regulatory T cells in experimental transplantation

C. Moore, C. Fuentes, D. Sauma, J. Morales, M. R. Bono, M. Rosemblatt, J. A. Fierro

Resultado de la investigación: Contribución a una revistaArtículo

3 Citas (Scopus)

Resumen

Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β and interleukin (IL) 2, generated allogeneic regulatory T cells de novo. These cells were able to inhibit skin rejection in adoptive transfer experiments. The generation of regulatory T cells ex vivo with retinoic acid, TGF-β, and IL-2 represents a new step toward specific regulation of allogeneic immune responses.

Idioma originalInglés
Páginas (desde-hasta)2334-2337
Número de páginas4
PublicaciónTransplantation Proceedings
Volumen43
N.º6
DOI
EstadoPublicada - jul 2011

Áreas temáticas de ASJC Scopus

  • Cirugía
  • Transplantes

Huella Profundice en los temas de investigación de 'Retinoic acid generates regulatory T cells in experimental transplantation'. En conjunto forman una huella única.

  • Citar esto

    Moore, C., Fuentes, C., Sauma, D., Morales, J., Bono, M. R., Rosemblatt, M., & Fierro, J. A. (2011). Retinoic acid generates regulatory T cells in experimental transplantation. Transplantation Proceedings, 43(6), 2334-2337. https://doi.org/10.1016/j.transproceed.2011.06.057