Retinoic acid as a modulator of T cell immunity

Maria Rosa Bono, Gabriela Tejon, Felipe Flores-Santibañez, Dominique Fernandez, Mario Rosemblatt, Daniela Sauma

Resultado de la investigación: Review article

33 Citas (Scopus)

Resumen

Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surface integrity, erythrocyte production, reproduction, and normal immune function. Vitamin A deficiency is one of the most common micronutrient deficiencies worldwide and is associated with defects in adaptive immunity. Reports from epidemiological studies, clinical trials and experimental studies have clearly demonstrated that vitamin A plays a central role in immunity and that its deficiency is the cause of broad immune alterations including decreased humoral and cellular responses, inadequate immune regulation, weak response to vaccines and poor lymphoid organ development. In this review, we will examine the role of vitamin A in immunity and focus on several aspects of T cell biology such as T helper cell differentiation, function and homing, as well as lymphoid organ development. Further, we will provide an overview of the effects of vitamin A deficiency in the adaptive immune responses and how retinoic acid, through its effect on T cells can fine-tune the balance between tolerance and immunity.

Idioma originalEnglish
Número de artículo349
PublicaciónNutrients
Volumen8
N.º6
DOI
EstadoPublished - 13 jun 2016

Huella dactilar

retinoic acid
Tretinoin
Vitamin A
vitamin A
Immunity
T-lymphocytes
immunity
T-Lymphocytes
Vitamin A Deficiency
vitamin A deficiency
Adaptive Immunity
Cell Differentiation
Micronutrients
Cellular Immunity
cell differentiation
cell biology
cell-mediated immunity
epidemiological studies
Reproduction
Cell Biology

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Citar esto

Bono, M. R., Tejon, G., Flores-Santibañez, F., Fernandez, D., Rosemblatt, M., & Sauma, D. (2016). Retinoic acid as a modulator of T cell immunity. Nutrients, 8(6), [349]. https://doi.org/10.3390/nu8060349
Bono, Maria Rosa ; Tejon, Gabriela ; Flores-Santibañez, Felipe ; Fernandez, Dominique ; Rosemblatt, Mario ; Sauma, Daniela. / Retinoic acid as a modulator of T cell immunity. En: Nutrients. 2016 ; Vol. 8, N.º 6.
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Bono, MR, Tejon, G, Flores-Santibañez, F, Fernandez, D, Rosemblatt, M & Sauma, D 2016, 'Retinoic acid as a modulator of T cell immunity', Nutrients, vol. 8, n.º 6, 349. https://doi.org/10.3390/nu8060349

Retinoic acid as a modulator of T cell immunity. / Bono, Maria Rosa; Tejon, Gabriela; Flores-Santibañez, Felipe; Fernandez, Dominique; Rosemblatt, Mario; Sauma, Daniela.

En: Nutrients, Vol. 8, N.º 6, 349, 13.06.2016.

Resultado de la investigación: Review article

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AU - Bono, Maria Rosa

AU - Tejon, Gabriela

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AU - Fernandez, Dominique

AU - Rosemblatt, Mario

AU - Sauma, Daniela

PY - 2016/6/13

Y1 - 2016/6/13

N2 - Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surface integrity, erythrocyte production, reproduction, and normal immune function. Vitamin A deficiency is one of the most common micronutrient deficiencies worldwide and is associated with defects in adaptive immunity. Reports from epidemiological studies, clinical trials and experimental studies have clearly demonstrated that vitamin A plays a central role in immunity and that its deficiency is the cause of broad immune alterations including decreased humoral and cellular responses, inadequate immune regulation, weak response to vaccines and poor lymphoid organ development. In this review, we will examine the role of vitamin A in immunity and focus on several aspects of T cell biology such as T helper cell differentiation, function and homing, as well as lymphoid organ development. Further, we will provide an overview of the effects of vitamin A deficiency in the adaptive immune responses and how retinoic acid, through its effect on T cells can fine-tune the balance between tolerance and immunity.

AB - Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surface integrity, erythrocyte production, reproduction, and normal immune function. Vitamin A deficiency is one of the most common micronutrient deficiencies worldwide and is associated with defects in adaptive immunity. Reports from epidemiological studies, clinical trials and experimental studies have clearly demonstrated that vitamin A plays a central role in immunity and that its deficiency is the cause of broad immune alterations including decreased humoral and cellular responses, inadequate immune regulation, weak response to vaccines and poor lymphoid organ development. In this review, we will examine the role of vitamin A in immunity and focus on several aspects of T cell biology such as T helper cell differentiation, function and homing, as well as lymphoid organ development. Further, we will provide an overview of the effects of vitamin A deficiency in the adaptive immune responses and how retinoic acid, through its effect on T cells can fine-tune the balance between tolerance and immunity.

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Bono MR, Tejon G, Flores-Santibañez F, Fernandez D, Rosemblatt M, Sauma D. Retinoic acid as a modulator of T cell immunity. Nutrients. 2016 jun 13;8(6). 349. https://doi.org/10.3390/nu8060349