Rendimiento de índices pronósticos en infección asociada a Clostridium difficile grave Análisis retrospectivo en un hospital universitario

Cristian Hernández-Rocha, Rodrigo Tejos Sufan, Ángela Plaza-Garrido, Jonathan Barra-Carrasco, Carlos Agüero Luengo, Gonzalo Inostroza Levy, Patricio Ibáñez Lazo, Ana M. Guzmán-Durán, Daniel Paredes-Sabja, M. Elena Molina Pezoa, Manuel Álvarez-Lobos

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)

Resumen

Introduction: By consensus severe, Clostridium difficile-associated infection (CDAI) is one that results in hospitalization in ICU, colectomy or death within 30 days. Multiple prognostic indices (IP) attempt to predict these adverse events. Objective: To evaluate the performance of 4 PI in predicting severe CDI. Methods: Hospitalized patients ≥18 years old with ICD were retrospectively evaluated. Patients with recurrent infection or hematological cancer were excluded. Four PI were evaluated: UPMC version 1, Calgary version 1, Hines VA and Calgary version 2. Results: Seven of 81 patients (8.1%) met the definition of severe CDI. Positive predicted value (PPV) and negative predicted value (NPV) of PI ranged from 20-75% and 91.3-95.7%, respectively. Only Hines VA index had a satisfactory Kappa index (0.74; 95% CI 0.41-1) with a PPV of 75% and NPV of 95,7%. However, because of the variables included, this PI could be calculated only in 32.6% of patients. Conclusion: Hines VA index has the best predicted value and agreement to rule out a severe CDI. Like others PI it has the limitation of including difficult variables to assess in all patients and tends to overestimate an unfavorable course.

Título traducido de la contribuciónPerformance of prognostic index in severe Clostridium difficile-associated infection Retrospective analysis in a university hospital
Idioma originalEspañol
Páginas (desde-hasta)659-665
Número de páginas7
PublicaciónRevista Chilena de Infectologia
Volumen31
N.º6
DOI
EstadoPublicada - 2014

Palabras clave

  • Antibiotics-associated colitis
  • Clinical prognostic rules
  • Clostridium difficile-associated infection
  • Complications
  • Risk factors
  • Severity

Áreas temáticas de ASJC Scopus

  • Salud pública, medioambiental y laboral
  • Enfermedades infecciosas

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