Relación neutrófilo a linfocito, recuento linfocitario e índices de actividad inflamatoria como factores pronóstico en infecciones por SARS-CoV-2: Un estudio de cohorte prospectiva

Felipe Martínez, Dominique Boisier, Constanza Vergara, Jaime Vidal

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Introduction: Patients with COVID-19 can develop respiratory failure requiring treatment with invasive mechanical ventilation (IMV) and death. It is important to have clinical predictors of these outcomes. Objetives: To establish the diagnostic accuracy of neutrophil to lymphocyte ratios (NLr) in predicting the need of IMV and survival amongst patients with COVID-19 and to compare this accuracy with other laboratory tests. Methodology: Prospective cohort study of hospitalized patients with a SArS-CoV-2 infection confirmed by rT-PCr. Clinical, demographic and laboratory predictors were assessed, including LDH, C-reactive protein, absolute lymphocyte counts, serum ferritin and NLr. Statistical analyses were undertaken using receiver-operator characteristics (rOC) curves, which were in turn compared using the method described by Hanley and McNeal. Results: One hundred and twelve patients were studied, most were male (60.7%) with a mean age of 63.4 ± 18.3 years. Twenty-two patients required IMV during their stay and 28 died. The NLr showed a good diagnostic accuracy in detecting patients that would require IMV (AUC 0.70, 95% CI 0.57-0.86) or died during the hospitalization (AUC 0.83, 95%CI 0.75-0.91). A cutoff point of 5.5 or higher had an 80.8% sensitivity and 73.1% specificity in detecting patients that died during their stay. Conclusions. NLr showed favorable diagnostic properties in detecting patients with COVID-19 at risk of adverse outcomes. Its wide availability and low cost are desirable features that might facilitate its implementation in routine clinical practice.

Título traducido de la contribuciónNeutrophil to lymphocite ratio and inflammatory biomarkers as prognostic factors amongst patients with COVID-19: A prospective cohort study
Idioma originalEspañol
Páginas (desde-hasta)80-87
Número de páginas8
PublicaciónRevista Chilena de Anestesia
Volumen51
N.º1
DOI
EstadoPublicada - 2022

Palabras clave

  • COVID-19
  • Lymphocytes
  • Mechanical ventilation
  • Neutrophils
  • Prognosis
  • SArS-CoV-2
  • Survival

Áreas temáticas de ASJC Scopus

  • Anestesiología y analgésicos

Huella

Profundice en los temas de investigación de 'Relación neutrófilo a linfocito, recuento linfocitario e índices de actividad inflamatoria como factores pronóstico en infecciones por SARS-CoV-2: Un estudio de cohorte prospectiva'. En conjunto forman una huella única.

Citar esto