Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells

Hugo González, Francisco Contreras, Rodrigo Pacheco

Resultado de la investigación: Review article

19 Citas (Scopus)

Resumen

Neuroinflammation constitutes a fundamental process involved in the physiopathology of Parkinson’s disease (PD). Microglial cells play a central role in the outcome of neuroinflammation and consequent neurodegeneration of dopaminergic neurons in the substantia nigra. Current evidence indicates that CD4+ T-cells infiltrate the central nervous system (CNS) in PD, where they play a critical role determining the functional phenotype of microglia, thus regulating the progression of the neurodegenerative process. Here, we first analysed the pathogenic role of inflammatory phenotypes and the beneficial role of anti-inflammatory phenotypes of encephalitogenic CD4+ T-cells involved in the physiopathology of PD. Next, we discussed how alterations of neurotransmitter levels observed in the basal ganglia throughout the time course of PD progression could be strongly affecting the behaviour of encephalitogenic CD4+ T-cells and thereby the outcome of the neuroinflammatory process and the consequent neurodegeneration of dopaminergic neurons. Afterward, we integrated the evidence indicating the involvement of an antigen-specific immune response mediated by T-cells and B-cells against CNS-derived self-constituents in PD. Consistent with the involvement of a relevant autoimmune component in PD, we also reviewed the polymorphisms of both, class I and class II major histocompatibility complexes, associated to the risk of PD. Overall, this study gives an overview of how an autoimmune component involved in PD plays a fundamental role in the progression of the neurodegenerative process.

Idioma originalEnglish
Páginas (desde-hasta)561-575
Número de páginas15
PublicaciónJournal of NeuroImmune Pharmacology
Volumen10
N.º4
DOI
EstadoPublished - 1 dic 2015

Huella dactilar

Parkinson Disease
T-Lymphocytes
Dopaminergic Neurons
Phenotype
Central Nervous System
Histocompatibility Antigens Class II
Microglia
Substantia Nigra
Basal Ganglia
Major Histocompatibility Complex
Neurotransmitter Agents
Disease Progression
B-Lymphocytes
Anti-Inflammatory Agents

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Citar esto

González, Hugo ; Contreras, Francisco ; Pacheco, Rodrigo. / Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells. En: Journal of NeuroImmune Pharmacology. 2015 ; Vol. 10, N.º 4. pp. 561-575.
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Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells. / González, Hugo; Contreras, Francisco; Pacheco, Rodrigo.

En: Journal of NeuroImmune Pharmacology, Vol. 10, N.º 4, 01.12.2015, p. 561-575.

Resultado de la investigación: Review article

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