Recent advances in germination of Clostridium spores

Valeria Olguín-Araneda, Saeed Banawas, Mahfuzur R. Sarker, Daniel Paredes-Sabja

Resultado de la investigación: Article

Resumen

Members of Clostridium genus are a diverse group of anaerobic spore-formers that includes several pathogenic species. Their anaerobic requirement enhances the importance of the dormant spore morphotype during infection, persistence and transmission. Bacterial spores are metabolically inactive and may survive for long times in the environment and germinate in presence of nutrients termed germinants. Recent progress with spores of several Clostridium species has identified the germinant receptors (GRs) involved in nutrient germinant recognition and initiation of spore germination. Signal transduction from GRs to the downstream effectors remains poorly understood but involves the release of dipicolinic acid. Two mechanistically different cortex hydrolytic machineries are present in Clostridium spores. Recent studies have also shed light into novel biological events that occur during spore formation (accumulation of transcriptional units) and transcription during early spore outgrowth. In summary, this review will cover all of the recent advances in Clostridium spore germination.

Idioma originalEnglish
PublicaciónResearch in Microbiology
DOI
EstadoAccepted/In press - 2014

Huella dactilar

Clostridium
Germination
Spores
Bacterial Spores
Food
Infectious Disease Transmission
Signal Transduction

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Medicine(all)

Citar esto

Olguín-Araneda, Valeria ; Banawas, Saeed ; Sarker, Mahfuzur R. ; Paredes-Sabja, Daniel. / Recent advances in germination of Clostridium spores. En: Research in Microbiology. 2014.
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abstract = "Members of Clostridium genus are a diverse group of anaerobic spore-formers that includes several pathogenic species. Their anaerobic requirement enhances the importance of the dormant spore morphotype during infection, persistence and transmission. Bacterial spores are metabolically inactive and may survive for long times in the environment and germinate in presence of nutrients termed germinants. Recent progress with spores of several Clostridium species has identified the germinant receptors (GRs) involved in nutrient germinant recognition and initiation of spore germination. Signal transduction from GRs to the downstream effectors remains poorly understood but involves the release of dipicolinic acid. Two mechanistically different cortex hydrolytic machineries are present in Clostridium spores. Recent studies have also shed light into novel biological events that occur during spore formation (accumulation of transcriptional units) and transcription during early spore outgrowth. In summary, this review will cover all of the recent advances in Clostridium spore germination.",
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Recent advances in germination of Clostridium spores. / Olguín-Araneda, Valeria; Banawas, Saeed; Sarker, Mahfuzur R.; Paredes-Sabja, Daniel.

En: Research in Microbiology, 2014.

Resultado de la investigación: Article

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T1 - Recent advances in germination of Clostridium spores

AU - Olguín-Araneda, Valeria

AU - Banawas, Saeed

AU - Sarker, Mahfuzur R.

AU - Paredes-Sabja, Daniel

PY - 2014

Y1 - 2014

N2 - Members of Clostridium genus are a diverse group of anaerobic spore-formers that includes several pathogenic species. Their anaerobic requirement enhances the importance of the dormant spore morphotype during infection, persistence and transmission. Bacterial spores are metabolically inactive and may survive for long times in the environment and germinate in presence of nutrients termed germinants. Recent progress with spores of several Clostridium species has identified the germinant receptors (GRs) involved in nutrient germinant recognition and initiation of spore germination. Signal transduction from GRs to the downstream effectors remains poorly understood but involves the release of dipicolinic acid. Two mechanistically different cortex hydrolytic machineries are present in Clostridium spores. Recent studies have also shed light into novel biological events that occur during spore formation (accumulation of transcriptional units) and transcription during early spore outgrowth. In summary, this review will cover all of the recent advances in Clostridium spore germination.

AB - Members of Clostridium genus are a diverse group of anaerobic spore-formers that includes several pathogenic species. Their anaerobic requirement enhances the importance of the dormant spore morphotype during infection, persistence and transmission. Bacterial spores are metabolically inactive and may survive for long times in the environment and germinate in presence of nutrients termed germinants. Recent progress with spores of several Clostridium species has identified the germinant receptors (GRs) involved in nutrient germinant recognition and initiation of spore germination. Signal transduction from GRs to the downstream effectors remains poorly understood but involves the release of dipicolinic acid. Two mechanistically different cortex hydrolytic machineries are present in Clostridium spores. Recent studies have also shed light into novel biological events that occur during spore formation (accumulation of transcriptional units) and transcription during early spore outgrowth. In summary, this review will cover all of the recent advances in Clostridium spore germination.

KW - Clostridium

KW - Cortex hydrolysis

KW - Germinant receptors

KW - Germination

KW - Spores

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