Real-world data of non-invasive stimulation of the human insula-prefrontal cortices using deep TMS to treat anxiety for occupational stress and generalized anxiety disorder

Rodrigo Moraga-Amaro, Paula Muñoz, Tomás Villalobos, Sergio Linsambarth, Francisco Maldonado, Valeria Meirone, Bruno Femopase, Jimmy Stehberg

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Activation of the insula is found in all anxiety-related disorders and increased insular-prefrontal cortex (PFC) functional connectivity is associated with reduced anxiety. In this study, the combined stimulation of the insula and PFC using the dTMS H4 (insula+LPFC) and H2 (PFC) coils were used to reduce anxiety in 13 subjects experiencing occupational stress, and 55 participants suffering from generalized anxiety disorder (GAD). The combined HF stimulation of the insula and PFC significantly decreased anxiety scores according to the HARS, CAS, and STAI anxiety scales, leading to a reduction in anxiety according to HARS of 88.7% and 70.7% in participants with occupational stress and the clinical sample of participants diagnosed with GAD, respectively. The findings suggest that the prefrontal-insular axis is critical for the regulation of anxiety and its stimulation can be used for the treatment of anxiety in people suffering from occupational stress and GAD.

Idioma originalInglés
Número de artículo115036
PublicaciónPsychiatry Research
Volumen320
DOI
EstadoPublicada - feb. 2023

Áreas temáticas de ASJC Scopus

  • Psiquiatría y salud mental
  • Psiquiatría biológica

Huella

Profundice en los temas de investigación de 'Real-world data of non-invasive stimulation of the human insula-prefrontal cortices using deep TMS to treat anxiety for occupational stress and generalized anxiety disorder'. En conjunto forman una huella única.

Citar esto