Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

Franco Díaz; Camila Cores; Omar Atenas; Nicolás Rodríguez; Raúl Bustos; Pablo Cruces

doi:10.1097/INF.0000000000003169

Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

Franco Díaz, Camila Cores, Omar Atenas, Nicolás Rodríguez, Raúl Bustos, Pablo Cruces

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3 Citas (Scopus)

Resumen

Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.

Idioma original	Inglés
Páginas (desde-hasta)	e259-e262
Publicación	The Pediatric infectious disease journal
Volumen	40
N.º	7
DOI	https://doi.org/10.1097/INF.0000000000003169
Estado	Publicada - 1 jul. 2021

Áreas temáticas de ASJC Scopus

Pediatría, perinaltología y salud infantil
Microbiología (médica)
Enfermedades infecciosas

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10.1097/INF.0000000000003169

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title = "Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure",

abstract = "Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.",

author = "Franco D{\'i}az and Camila Cores and Omar Atenas and Nicol{\'a}s Rodr{\'i}guez and Ra{\'u}l Bustos and Pablo Cruces",

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AU - Díaz, Franco

AU - Cores, Camila

AU - Atenas, Omar

AU - Rodríguez, Nicolás

AU - Bustos, Raúl

AU - Cruces, Pablo

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.

AB - Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.

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Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

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