Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice

Lina M. Ruiz, Celia Salazar, Erik Jensen, Paula A. Ruiz, William Tiznado, Rodrigo A. Quintanilla, Marlen Barreto, Alvaro A. Elorza

Resultado de la investigación: Article

7 Citas (Scopus)

Resumen

Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase in O2- production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue. Therefore, because of its dual actions, we studied the effect of quercetin in vivo to analyze heart mitochondrial function and erythropoiesis. Mice were injected with 50 mg/kg of quercetin for 15 days. Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice. Along with an impaired antioxidant capacity in plasma, quercetin-treated mice showed a significant delay on erythropoiesis progression. Heart mitochondrial function was also impaired displaying more protein oxidation and less activity for IV, respectively, than no-treated mice. In addition, a significant reduction in the protein expression levels of Mitofusin 2 and Voltage-Dependent Anion Carrier was observed. All these results suggest that quercetin affects erythropoiesis and mitochondrial function and then its potential use as a dietary supplement should be reexamined.

Idioma originalEnglish
Número de artículo836301
PublicaciónOxidative Medicine and Cellular Longevity
Volumen2015
DOI
EstadoPublished - 2015

Huella dactilar

Erythropoiesis
Quercetin
Dietary Supplements
Dietary supplements
Antioxidants
Mitochondria
Ceruloplasmin
Mammals
Electron Transport
Flavonoids
Liver
Anions
Proteins
Adenosine Triphosphate
Body Weight
Insulin
Tissue
Plasmas
Oxidation
Electric potential

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology
  • Medicine(all)

Citar esto

Ruiz, Lina M. ; Salazar, Celia ; Jensen, Erik ; Ruiz, Paula A. ; Tiznado, William ; Quintanilla, Rodrigo A. ; Barreto, Marlen ; Elorza, Alvaro A. / Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. En: Oxidative Medicine and Cellular Longevity. 2015 ; Vol. 2015.
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abstract = "Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase in O2- production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue. Therefore, because of its dual actions, we studied the effect of quercetin in vivo to analyze heart mitochondrial function and erythropoiesis. Mice were injected with 50 mg/kg of quercetin for 15 days. Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice. Along with an impaired antioxidant capacity in plasma, quercetin-treated mice showed a significant delay on erythropoiesis progression. Heart mitochondrial function was also impaired displaying more protein oxidation and less activity for IV, respectively, than no-treated mice. In addition, a significant reduction in the protein expression levels of Mitofusin 2 and Voltage-Dependent Anion Carrier was observed. All these results suggest that quercetin affects erythropoiesis and mitochondrial function and then its potential use as a dietary supplement should be reexamined.",
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Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. / Ruiz, Lina M.; Salazar, Celia; Jensen, Erik; Ruiz, Paula A.; Tiznado, William; Quintanilla, Rodrigo A.; Barreto, Marlen; Elorza, Alvaro A.

En: Oxidative Medicine and Cellular Longevity, Vol. 2015, 836301, 2015.

Resultado de la investigación: Article

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AU - Salazar, Celia

AU - Jensen, Erik

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AU - Tiznado, William

AU - Quintanilla, Rodrigo A.

AU - Barreto, Marlen

AU - Elorza, Alvaro A.

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