Proteína Morfogenética Ósea y su Opción como tratamiento de la fisura alveolar

Francisca Uribe, Mario Cantín, Juan Pablo Alister, Cristián Vilos, Rodrigo Fariña, Sergio Olate

Resultado de la investigación: Article

1 Cita (Scopus)

Resumen

Bone morphogenetic protein (BMP) is an endogenous protein that has shown significant effects in the promotion of bone formation. BMP also has been described in the reconstruction of traumatic and pathological bone defects, including alveolar cleft, alveolar ridge augmentation, maxillary sinus elevation, and applications in post-extraction alveolus graft, and peri-implant surgery among others. Despite the advantages associated with the use of BMP, currently is applied in combination with collagen matrices, which has certain properties such as low mechanical resistance and a high burst initial release that diminish its effectiveness in bone formation. In this context, the development of novel systems with greater mechanical resistance and prolonged release of BMP, that lead to chemotaxis of mesenchymal cells, following by its differentiation to osteoblasts represents a major challenge that holds outstanding clinical potential for the stimulation of bone formation. In this paper, we describe the use of BMP for the reconstruction of alveolar clefts, and its advantages being administrated in polymeric microparticles as sustain release system with promising applications in the stimulation of bone formation.

Idioma originalSpanish
Páginas (desde-hasta)310-318
Número de páginas9
PublicaciónInternational Journal of Morphology
Volumen35
N.º1
DOI
EstadoPublished - 1 ene 2017

Huella dactilar

Bone Morphogenetic Proteins
Osteogenesis
Alveolar Ridge Augmentation
Therapeutics
Maxillary Sinus
Chemotaxis
Osteoblasts
Collagen
Transplants
Bone and Bones
Proteins

ASJC Scopus subject areas

  • Anatomy

Citar esto

Uribe, Francisca ; Cantín, Mario ; Alister, Juan Pablo ; Vilos, Cristián ; Fariña, Rodrigo ; Olate, Sergio. / Proteína Morfogenética Ósea y su Opción como tratamiento de la fisura alveolar. En: International Journal of Morphology. 2017 ; Vol. 35, N.º 1. pp. 310-318.
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Proteína Morfogenética Ósea y su Opción como tratamiento de la fisura alveolar. / Uribe, Francisca; Cantín, Mario; Alister, Juan Pablo; Vilos, Cristián; Fariña, Rodrigo; Olate, Sergio.

En: International Journal of Morphology, Vol. 35, N.º 1, 01.01.2017, p. 310-318.

Resultado de la investigación: Article

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