Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice

Hugo F. Miranda, Viviana Noriega, Juan Carlos Prieto

Resultado de la investigación: Article

9 Citas (Scopus)

Resumen

In the treatment of acute and chronic pain the most frequently used drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), e.g., paracetamol; opioids, e.g., tramadol, and a group of drugs called coanalgesics or adjuvants (e.g., antidepressants, anticonvulsants). The aim of this work was to determine the nature of the interaction induced by intraperitoneal or intrathecal coadministration of paracetamol and tramadol. The type of interaction was evaluated by means of isobolographic analysis, using the acetic acid writhing test as an algesiometer in mice. In addition, the involvement of opioid receptors in the interaction was studied using naltrexone, a non-selective opioid receptor antagonist. The administration of paracetamol or tramadol induced a dose-dependent antinociceptive activity in the assay. The dose-response curves were characterized by equal efficacy but different potencies, being i.t. paracetamol 11.84 times more potent than i.p. paracetamol, and i.t. tramadol 3.54 times more potent than the i.p. tramadol. The isobolographic analysis indicates a synergistic interaction between the coadministration of i.p. or i.t. paracetamol with tramadol. The interaction index values were similar for the i.p. and i.t. coadministration with values of 0.414 and 0.364, respectively. The different mechanisms of action of paracetamol and tramadol strongly explain the analgesic synergism between them, in agreement with the general theory of drug interaction. This synergic interaction was not modified by the non selective opioid antagonist, naltrexone. This association could be of clinical significance in the treatment of pain with a reduction of doses and adverse effects.

Idioma originalEnglish
Páginas (desde-hasta)72-76
Número de páginas5
PublicaciónPharmacology Biochemistry and Behavior
Volumen102
N.º1
DOI
EstadoPublished - 1 jul 2012

Huella dactilar

Tramadol
Naltrexone
Acetaminophen
Narcotic Antagonists
Drug interactions
Pharmaceutical Preparations
Acute Pain
Opioid Receptors
Drug Interactions
Chronic Pain
Acetic Acid
Anticonvulsants
Opioid Analgesics
Antidepressive Agents
Analgesics
Assays
Anti-Inflammatory Agents
Association reactions
Pain
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Citar esto

Miranda, Hugo F. ; Noriega, Viviana ; Prieto, Juan Carlos. / Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice. En: Pharmacology Biochemistry and Behavior. 2012 ; Vol. 102, N.º 1. pp. 72-76.
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abstract = "In the treatment of acute and chronic pain the most frequently used drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), e.g., paracetamol; opioids, e.g., tramadol, and a group of drugs called coanalgesics or adjuvants (e.g., antidepressants, anticonvulsants). The aim of this work was to determine the nature of the interaction induced by intraperitoneal or intrathecal coadministration of paracetamol and tramadol. The type of interaction was evaluated by means of isobolographic analysis, using the acetic acid writhing test as an algesiometer in mice. In addition, the involvement of opioid receptors in the interaction was studied using naltrexone, a non-selective opioid receptor antagonist. The administration of paracetamol or tramadol induced a dose-dependent antinociceptive activity in the assay. The dose-response curves were characterized by equal efficacy but different potencies, being i.t. paracetamol 11.84 times more potent than i.p. paracetamol, and i.t. tramadol 3.54 times more potent than the i.p. tramadol. The isobolographic analysis indicates a synergistic interaction between the coadministration of i.p. or i.t. paracetamol with tramadol. The interaction index values were similar for the i.p. and i.t. coadministration with values of 0.414 and 0.364, respectively. The different mechanisms of action of paracetamol and tramadol strongly explain the analgesic synergism between them, in agreement with the general theory of drug interaction. This synergic interaction was not modified by the non selective opioid antagonist, naltrexone. This association could be of clinical significance in the treatment of pain with a reduction of doses and adverse effects.",
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Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice. / Miranda, Hugo F.; Noriega, Viviana; Prieto, Juan Carlos.

En: Pharmacology Biochemistry and Behavior, Vol. 102, N.º 1, 01.07.2012, p. 72-76.

Resultado de la investigación: Article

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T1 - Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice

AU - Miranda, Hugo F.

AU - Noriega, Viviana

AU - Prieto, Juan Carlos

PY - 2012/7/1

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