Previous administration of indomethacin or naloxone did not influence ketorolac antinociception in mice

H. F. Miranda, F. Sierralta, G. Pinardi

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

24 Citas (Scopus)

Resumen

We studied the effects of the inhibition of prostaglandin biosynthesis and opioid antagonism in the antinociceptive action of ketorolac using the mouse acetic acid writhing test. Ketorolac was administered via the intraperitoneal, intrathecal, or intracerebroventricular routes. Although the ketorolac induced a significant dose-dependent antinociceptive effect, the intracerebroventricular administration was the most effective route. Indomethacin and naloxone pretreatments did not change the ketorolac-induced antinociception. The present findings suggest that this antinociceptive action of ketorolac is not mediated by the inhibition of prostaglandin biosynthesis nor by activation of opioid receptors.

Idioma originalInglés
Páginas (desde-hasta)750-753
Número de páginas4
PublicaciónAnesthesia and Analgesia
Volumen77
N.º4
DOI
EstadoPublicada - 1993

Áreas temáticas de ASJC Scopus

  • Anestesiología y analgésicos

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