Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano

Juan Carlos Flores, Karen Bohmwald, Janyra Espinoza, Cristina Jara, Marcela Peña, Rodrigo Hoyos-Bachiloglu, Carolina Iturriaga, Alexis M. Kalergis, Arturo Borzutzky

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Human respiratory syncytial virus (RSV) infection remains as a major cause of morbidity and mortality among pediatric population. Immune response is poor and unable to establish a long term effective protection against this virus. Of particular interest has been the description of extrapulmonary manifestations of RSV infection in liver, kidney, endocrine system, heart and brain, associated to infection of peripheral blood. In the central nervous system (CNS), recent studies in animals have suggested long term neurocognitive impairment due to a direct damage from the virus. This was prevented in rats by a recombinant BCG vaccine expressing a nucleoprotein N of RSV that produces an effective immune response against the virus, not allowing its dissemination to the CNS. These findings in animal models highlight the importance of conducting more specific studies in children affected with severe infection by RSV. Therefore, our group is currently conducting an assessment of the possible long-term cognitive impairment in children under 2 years. The results of this study could be a strong argument to continue looking for an effective method for protecting against RSV infection.

Título traducido de la contribuciónPotential neurocognitive consequences of infection by human respiratory syncytial virus
Idioma originalEspañol
Páginas (desde-hasta)537-542
Número de páginas6
PublicaciónRevista Chilena de Infectologia
Volumen33
N.º5
DOI
EstadoPublicada - 1 oct 2016
Publicado de forma externa

Palabras clave

  • Encephalitis
  • Encephalopathy
  • Human respiratory syncytial virus
  • Learning

Áreas temáticas de ASJC Scopus

  • Salud pública, medioambiental y laboral
  • Enfermedades infecciosas

Huella

Profundice en los temas de investigación de 'Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano'. En conjunto forman una huella única.

Citar esto