Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano

Juan Carlos Flores, Karen Bohmwald, Janyra Espinoza, Cristina Jara, Marcela Peña, Rodrigo Hoyos-Bachiloglu, Carolina Iturriaga, Alexis M. Kalergis, Arturo Borzutzky

Resultado de la investigación: Article

Resumen

Human respiratory syncytial virus (RSV) infection remains as a major cause of morbidity and mortality among pediatric population. Immune response is poor and unable to establish a long term effective protection against this virus. Of particular interest has been the description of extrapulmonary manifestations of RSV infection in liver, kidney, endocrine system, heart and brain, associated to infection of peripheral blood. In the central nervous system (CNS), recent studies in animals have suggested long term neurocognitive impairment due to a direct damage from the virus. This was prevented in rats by a recombinant BCG vaccine expressing a nucleoprotein N of RSV that produces an effective immune response against the virus, not allowing its dissemination to the CNS. These findings in animal models highlight the importance of conducting more specific studies in children affected with severe infection by RSV. Therefore, our group is currently conducting an assessment of the possible long-term cognitive impairment in children under 2 years. The results of this study could be a strong argument to continue looking for an effective method for protecting against RSV infection.

Idioma originalSpanish
Páginas (desde-hasta)537-542
Número de páginas6
PublicaciónRevista Chilena de Infectologia
Volumen33
N.º5
DOI
EstadoPublished - 1 oct 2016
Publicado de forma externa

Huella dactilar

Human respiratory syncytial virus
Respiratory Syncytial Virus Infections
Viruses
Infection
Central Nervous System
BCG Vaccine
Synthetic Vaccines
Endocrine System
Nucleoproteins
Respiratory Syncytial Viruses
Animal Models
Pediatrics
Morbidity
Kidney
Mortality
Liver
Brain
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Citar esto

Flores, J. C., Bohmwald, K., Espinoza, J., Jara, C., Peña, M., Hoyos-Bachiloglu, R., ... Borzutzky, A. (2016). Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano. Revista Chilena de Infectologia, 33(5), 537-542. https://doi.org/10.4067/S0716-10182016000500008
Flores, Juan Carlos ; Bohmwald, Karen ; Espinoza, Janyra ; Jara, Cristina ; Peña, Marcela ; Hoyos-Bachiloglu, Rodrigo ; Iturriaga, Carolina ; Kalergis, Alexis M. ; Borzutzky, Arturo. / Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano. En: Revista Chilena de Infectologia. 2016 ; Vol. 33, N.º 5. pp. 537-542.
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Flores, JC, Bohmwald, K, Espinoza, J, Jara, C, Peña, M, Hoyos-Bachiloglu, R, Iturriaga, C, Kalergis, AM & Borzutzky, A 2016, 'Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano', Revista Chilena de Infectologia, vol. 33, n.º 5, pp. 537-542. https://doi.org/10.4067/S0716-10182016000500008

Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano. / Flores, Juan Carlos; Bohmwald, Karen; Espinoza, Janyra; Jara, Cristina; Peña, Marcela; Hoyos-Bachiloglu, Rodrigo; Iturriaga, Carolina; Kalergis, Alexis M.; Borzutzky, Arturo.

En: Revista Chilena de Infectologia, Vol. 33, N.º 5, 01.10.2016, p. 537-542.

Resultado de la investigación: Article

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