Plasma progesterone levels following subdermal implantation of progesterone pellets in lactating women

H. B. Croxatto, S. Diaz, O. Peralta, A. M. Salvatierra, A. Brandeis

Resultado de la investigación: Article

5 Citas (Scopus)

Resumen

The magnitude and duration of elevated plasma progesterone levels resulting from subdermal implantation of progesterone pellets were investigated in full nursing women. This condition was chosen because it is associated with a low rate of ovulation and minimal endogenous progesterone production. In addition, treatment with progesterone pellets was intended to be a substutute for oral or parenteral administration of synthetic progestogens to nursing mothers. A control group of full nursing women receiving no hormones provided blood samples so that basal plasma progesterone levels from the second to the sixth post-partum month could be assessed. Progesterone pellets were implanted subdermally on day 30-35 after delivery. Insertion of 2, 4 or 6 pellets each containing 100 mg of progesterone caused an initial elevation of plasma progesterone to 5.9, 9.9 and 13.5 nmol/l, respectively. This initial elevation was followed by a gradual decline, so that basal levels were attained at 70, 100 and 150 days after insertion of 2, 4 or 6 pellets. Implantation of 6 progesterone pellets led to a significant decrease in the ovulation rate of nursing women. These results indicate that subdermal implantation of 6 progesterone pellets can provide biologically effective levels of the hormone for up to 5 months.

Idioma originalEnglish
Páginas (desde-hasta)630-633
Número de páginas4
PublicaciónActa Endocrinologica
Volumen100
N.º4
EstadoPublished - 1982

Huella dactilar

Progesterone
Nursing
Ovulation
Progesterone Congeners
Hormones
Mothers
Control Groups

ASJC Scopus subject areas

  • Endocrinology

Citar esto

Croxatto, H. B. ; Diaz, S. ; Peralta, O. ; Salvatierra, A. M. ; Brandeis, A. / Plasma progesterone levels following subdermal implantation of progesterone pellets in lactating women. En: Acta Endocrinologica. 1982 ; Vol. 100, N.º 4. pp. 630-633.
@article{7eeda73487ae4c449f5787189e86d662,
title = "Plasma progesterone levels following subdermal implantation of progesterone pellets in lactating women",
abstract = "The magnitude and duration of elevated plasma progesterone levels resulting from subdermal implantation of progesterone pellets were investigated in full nursing women. This condition was chosen because it is associated with a low rate of ovulation and minimal endogenous progesterone production. In addition, treatment with progesterone pellets was intended to be a substutute for oral or parenteral administration of synthetic progestogens to nursing mothers. A control group of full nursing women receiving no hormones provided blood samples so that basal plasma progesterone levels from the second to the sixth post-partum month could be assessed. Progesterone pellets were implanted subdermally on day 30-35 after delivery. Insertion of 2, 4 or 6 pellets each containing 100 mg of progesterone caused an initial elevation of plasma progesterone to 5.9, 9.9 and 13.5 nmol/l, respectively. This initial elevation was followed by a gradual decline, so that basal levels were attained at 70, 100 and 150 days after insertion of 2, 4 or 6 pellets. Implantation of 6 progesterone pellets led to a significant decrease in the ovulation rate of nursing women. These results indicate that subdermal implantation of 6 progesterone pellets can provide biologically effective levels of the hormone for up to 5 months.",
author = "Croxatto, {H. B.} and S. Diaz and O. Peralta and Salvatierra, {A. M.} and A. Brandeis",
year = "1982",
language = "English",
volume = "100",
pages = "630--633",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "4",

}

Croxatto, HB, Diaz, S, Peralta, O, Salvatierra, AM & Brandeis, A 1982, 'Plasma progesterone levels following subdermal implantation of progesterone pellets in lactating women', Acta Endocrinologica, vol. 100, n.º 4, pp. 630-633.

Plasma progesterone levels following subdermal implantation of progesterone pellets in lactating women. / Croxatto, H. B.; Diaz, S.; Peralta, O.; Salvatierra, A. M.; Brandeis, A.

En: Acta Endocrinologica, Vol. 100, N.º 4, 1982, p. 630-633.

Resultado de la investigación: Article

TY - JOUR

T1 - Plasma progesterone levels following subdermal implantation of progesterone pellets in lactating women

AU - Croxatto, H. B.

AU - Diaz, S.

AU - Peralta, O.

AU - Salvatierra, A. M.

AU - Brandeis, A.

PY - 1982

Y1 - 1982

N2 - The magnitude and duration of elevated plasma progesterone levels resulting from subdermal implantation of progesterone pellets were investigated in full nursing women. This condition was chosen because it is associated with a low rate of ovulation and minimal endogenous progesterone production. In addition, treatment with progesterone pellets was intended to be a substutute for oral or parenteral administration of synthetic progestogens to nursing mothers. A control group of full nursing women receiving no hormones provided blood samples so that basal plasma progesterone levels from the second to the sixth post-partum month could be assessed. Progesterone pellets were implanted subdermally on day 30-35 after delivery. Insertion of 2, 4 or 6 pellets each containing 100 mg of progesterone caused an initial elevation of plasma progesterone to 5.9, 9.9 and 13.5 nmol/l, respectively. This initial elevation was followed by a gradual decline, so that basal levels were attained at 70, 100 and 150 days after insertion of 2, 4 or 6 pellets. Implantation of 6 progesterone pellets led to a significant decrease in the ovulation rate of nursing women. These results indicate that subdermal implantation of 6 progesterone pellets can provide biologically effective levels of the hormone for up to 5 months.

AB - The magnitude and duration of elevated plasma progesterone levels resulting from subdermal implantation of progesterone pellets were investigated in full nursing women. This condition was chosen because it is associated with a low rate of ovulation and minimal endogenous progesterone production. In addition, treatment with progesterone pellets was intended to be a substutute for oral or parenteral administration of synthetic progestogens to nursing mothers. A control group of full nursing women receiving no hormones provided blood samples so that basal plasma progesterone levels from the second to the sixth post-partum month could be assessed. Progesterone pellets were implanted subdermally on day 30-35 after delivery. Insertion of 2, 4 or 6 pellets each containing 100 mg of progesterone caused an initial elevation of plasma progesterone to 5.9, 9.9 and 13.5 nmol/l, respectively. This initial elevation was followed by a gradual decline, so that basal levels were attained at 70, 100 and 150 days after insertion of 2, 4 or 6 pellets. Implantation of 6 progesterone pellets led to a significant decrease in the ovulation rate of nursing women. These results indicate that subdermal implantation of 6 progesterone pellets can provide biologically effective levels of the hormone for up to 5 months.

UR - http://www.scopus.com/inward/record.url?scp=0019942603&partnerID=8YFLogxK

M3 - Article

VL - 100

SP - 630

EP - 633

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 4

ER -