TY - JOUR
T1 - Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder
AU - Plaza-Diaz, Julio
AU - Radar, Ana Mei
AU - Baig, Aiman Tariq
AU - Leyba, Marcos Federico
AU - Costabel, Maria Macarena
AU - Zavala-Crichton, Juan Pablo
AU - Sanchez-Martinez, Javier
AU - MacKenzie, Alex E.
AU - Solis-Urra, Patricio
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASD-related symptoms.
AB - It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASD-related symptoms.
KW - autism spectrum disorder
KW - children
KW - genetics
KW - intestinal microbiota
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85144681342&partnerID=8YFLogxK
U2 - 10.3390/children9121834
DO - 10.3390/children9121834
M3 - Review article
AN - SCOPUS:85144681342
SN - 2227-9067
VL - 9
JO - Children
JF - Children
IS - 12
M1 - 1834
ER -