Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity

R. Ramírez-Barrantes, C. Cordova, H. Poblete, P. Muñoz, I. Marchant, F. Wianny, P. Olivero

Resultado de la investigación: Review article

16 Citas (Scopus)

Resumen

The development of new strategies to renew and repair neuronal networks using neural plasticity induced by stem cell graft could enable new therapies to cure diseases that were considered lethal until now. In adequate microenvironment a neuronal progenitor must receive molecular signal of a specific cellular context to determine fate, differentiation, and location. TRPV1, a nonselective calcium channel, is expressed in neurogenic regions of the brain like the subgranular zone of the hippocampal dentate gyrus and the telencephalic subventricular zone, being valuable for neural differentiation and neural plasticity. Current data show that TRPV1 is involved in several neuronal functions as cytoskeleton dynamics, cell migration, survival, and regeneration of injured neurons, incorporating several stimuli in neurogenesis and network integration. The function of TRPV1 in the brain is under intensive investigation, due to multiple places where it has been detected and its sensitivity for different chemical and physical agonists, and a new role of TRPV1 in brain function is now emerging as a molecular tool for survival and control of neural stem cells.

Idioma originalEnglish
Número de artículo1568145
PublicaciónNeural Plasticity
Volumen2016
DOI
EstadoPublished - 1 ene 2016

Huella dactilar

Neuronal Plasticity
Neurogenesis
Brain
Telencephalon
Parahippocampal Gyrus
Neural Stem Cells
Lateral Ventricles
Dentate Gyrus
Calcium Channels
Cytoskeleton
Cell Movement
Regeneration
Cell Survival
Stem Cells
Transplants
Neurons
Therapeutics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Citar esto

Ramírez-Barrantes, R., Cordova, C., Poblete, H., Muñoz, P., Marchant, I., Wianny, F., & Olivero, P. (2016). Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity. Neural Plasticity, 2016, [1568145]. https://doi.org/10.1155/2016/1568145
Ramírez-Barrantes, R. ; Cordova, C. ; Poblete, H. ; Muñoz, P. ; Marchant, I. ; Wianny, F. ; Olivero, P. / Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity. En: Neural Plasticity. 2016 ; Vol. 2016.
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Ramírez-Barrantes, R, Cordova, C, Poblete, H, Muñoz, P, Marchant, I, Wianny, F & Olivero, P 2016, 'Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity', Neural Plasticity, vol. 2016, 1568145. https://doi.org/10.1155/2016/1568145

Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity. / Ramírez-Barrantes, R.; Cordova, C.; Poblete, H.; Muñoz, P.; Marchant, I.; Wianny, F.; Olivero, P.

En: Neural Plasticity, Vol. 2016, 1568145, 01.01.2016.

Resultado de la investigación: Review article

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AU - Wianny, F.

AU - Olivero, P.

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