Perfil de efectividad y seguridad de preparaciones orales de cannabis para el tratamiento de epilepsias refractarias en la población infantojuvenil. Una revisión de alcance

Bernardo Burgos, Igor Cigarroa, David Toloza-Ramírez

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Introduction: Refractory epilepsies (RE) are a common neurological condition expressed in childhood and adulthood, highlighting the current use of cannabis as an alternative treatment. Oral Cannabis Preparations (OCP) have demonstrated effectiveness in the adult population; however, knowledge is limited in the infant-young population. Aim: To synthesize the available evidence on the efficacy and safety of OCP for the treatment of refractory epilepsies in the infant-young population. Methods: The present study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines and included studies from January 2013 until December 2020 from electronic databases, including SciELO, ScienceDirect, PubMed, and Web of Science. Results: 7 articles were included in this scoping review for critical analysis. The results indicate that pharmaceutical and artisanal origin OCP has 41.3% effectiveness in reducing seizures and low safety after administration (27.4%). Likewise, after administration, the most frequent adverse symptoms were somnolence/fatigue, weight loss/decreased appetite, and irritability/ aggressiveness. Conclusion: The low levels of effectiveness and safety of OCP suggest that they should be administered with caution and as a complementary treatment and not as the first choice for managi ng RE in the infant-young population.

Título traducido de la contribuciónEffectiveness and safety profile of oral cannabis preparations for the treatment of refractory epilepsies in infant-young population: A Scoping Review
Idioma originalEspañol
Páginas (desde-hasta)62-74
Número de páginas13
PublicaciónRevista Ecuatoriana de Neurologia
Volumen32
N.º1
DOI
EstadoPublicada - 2023

Palabras clave

  • Cannabidiol
  • Cannabis
  • Refractory Epilepsy
  • Scoping Review
  • Seizures

Áreas temáticas de ASJC Scopus

  • Neurología
  • Neurología clínica

Huella

Profundice en los temas de investigación de 'Perfil de efectividad y seguridad de preparaciones orales de cannabis para el tratamiento de epilepsias refractarias en la población infantojuvenil. Una revisión de alcance'. En conjunto forman una huella única.

Citar esto