Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease

Francisco Morales-Zavala, Hector Arriagada, Natalia Hassan, Carolina Velasco, Ana Riveros, Alejandra R. Álvarez, Alicia N. Minniti, Ximena Rojas-Silva, Luis L. Muñoz, Rodrigo Vasquez, Katherine Rodriguez, Macarena Sanchez-Navarro, Ernest Giralt, Eyleen Araya, Rebeca Aldunate, Marcelo J. Kogan

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

59 Citas (Scopus)

Resumen

The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods were synthetized and stabilized with polyethylene glycols and modified with two kinds of peptides. The D1 peptide that recognizes toxic aggregates of Aβ, a peptide involved in Alzheimer's disease (AD); and the Angiopep 2 that can be used to deliver nanorods to the mammalian central nervous system. The nanoconjugates were characterized using absorption spectrophotometry, dynamic light scattering, and transmission electron microscopy, among other techniques. We determined that the nanoconjugate does not affect neuronal viability; it penetrates the cells, and decreases aggregation of Aβ peptide in vitro. We also showed that when we apply our nanosystem to a Caenorhabditis elegans AD model, the toxicity of aggregated Aβ peptide is decreased. This work may contribute to the development of therapies for AD based on metallic nanoparticles.

Idioma originalInglés
Páginas (desde-hasta)2341-2350
Número de páginas10
PublicaciónNanomedicine: Nanotechnology, Biology, and Medicine
Volumen13
N.º7
DOI
EstadoPublicada - 1 oct. 2017

Áreas temáticas de ASJC Scopus

  • Medicina (miscelánea)
  • Bioingeniería
  • Ingeniería biomédica
  • Medicina molecular
  • Ciencia de los Materiales General
  • Ciencias farmacéuticas

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