Pediatric Inflammatory Multisystem Syndrome Associated with SARS-CoV-2: A Case Series Quantitative Systematic Review

Raúl Bustos B, Juan Camilo Jaramillo-Bustamante, Pablo Vasquez-Hoyos, Pablo Cruces, Franco Díaz

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

Resumen

Pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) is infrequent, but children might present as a life-threatening disease. In a systematic quantitative review, we analyzed 11 studies of PIMS-TS, including 468 children reported before July 1, 2020. We found a myriad of clinical features, but we were able to describe common characteristics: previously healthy school-aged children, persistent fever and gastrointestinal symptoms, lymphopenia, and high inflammatory markers. Clinical syndromes such as myocarditis and Kawasaki disease were present in only one third of cases each one. Pediatric intensive care unit admission was frequent, although length of stay was less than 1 week, and mortality was low. Most patients received immunoglobulin or steroids, although the level of evidence for that treatment is low. The PIMS-ST was recently described, and the detailed quantitative pooled data will increase clinicians' awareness, improve diagnosis, and promptly start treatment. This analysis also highlights the necessity of future collaborative studies, given the heterogeneous nature of the PIMS-TS.

Idioma originalInglés
Páginas (desde-hasta)44-47
Número de páginas4
PublicaciónPediatric Emergency Care
Volumen37
N.º1
DOI
EstadoPublicada - 2021

Áreas temáticas de ASJC Scopus

  • Pediatría, perinaltología y salud infantil
  • Medicina de urgencias
  • Medicina (todo)

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