@article{f66052b8acf24d2b95f1d4a4b6020c3b,
title = "Pdgf1aa regulates zebrafish neural crest cells migration through Hif-1 in an oxygen-independent manner",
abstract = "The transcription factor Hif-1α regulates epithelial to mesenchymal transition and neural crest cell chemotaxis in Xenopus. Hif-1α is only stabilised under low oxygen levels, and the in vivo stabilisation of this factor in neural crest cells is poorly understood. Multiple oxygen-independent Hif-1α regulators have been described in cell cultures and cancer models. Among these, the PDGF pathway has been linked to neural crest development. The present study established a connection between the Pdgf pathway and Hif-1α stabilisation in zebrafish. Specifically, embryos with a disrupted Pdgf pathway were rescued by employing hif-1α mRNA through qPCR and immunohistochemistry techniques. The data suggest that oxygen levels in the neural crest are normal and that Pdgf1aa regulates neural crest migration through Hif-1α expression.",
author = "Espina, {J. A.} and Marchant, {C. L.} and {De Ferrari}, {G. V.} and Reyes, {A. E.}",
note = "Funding Information: This study was supported by: ?Fondo de Investigacion Cientifica y Tecnologica (FONDECYT 1150816 to A.E.R and FONDECYT 1180848 to G.V.D.), Consejo Nacional de Investigacion Cientifica y Tecnologica (CONICYT)/Fondo de Financiamiento de Gastos de Operaci?n (21130280)? to J.A.E., and DI-1354-16/RG by VRID Universidad Andres Belllo to A.E.R. Funding Information: This study was supported by: “Fondo de Investigacion Cientifica y Tecnologica ( FONDECYT 1150816 to A.E.R and FONDECYT 1180848 to G.V.D.), Consejo Nacional de Investigacion Cientifica y Tecnologica ( CONICYT )/Fondo de Financiamiento de Gastos de Operaci{\'o}n ( 21130280 )” to J.A.E., and DI-1354-16/RG by VRID Universidad Andres Belllo to A.E.R. Funding Information: This study was supported by: “Fondo de Investigacion Cientifica y Tecnologica (FONDECYT 1150816 to A.E.R and FONDECYT 1180848 to G.V.D.), Consejo Nacional de Investigacion Cientifica y Tecnologica (CONICYT)/Fondo de Financiamiento de Gastos de Operaci{\'o}n (21130280)” to J.A.E., and DI-1354-16/RG by VRID Universidad Andres Belllo to A.E.R. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.mod.2018.07.007",
language = "English",
volume = "154",
pages = "203--207",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
}
