Pathogen typing in the genomics era: MLST and the future of molecular epidemiology

Marcos Pérez-Losada, Patricia Cabezas, Eduardo Castro-Nallar, Keith A. Crandall

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

120 Citas (Scopus)

Resumen

Multi-locus sequence typing (MLST) is a high-resolution genetic typing approach to identify species and strains of pathogens impacting human health, agriculture (animals and plants), and biosafety. In this review, we outline the general concepts behind MLST, molecular approaches for obtaining MLST data, analytical approaches for MLST data, and the contributions MLST studies have made in a wide variety of areas. We then look at the future of MLST and their relative strengths and weaknesses with respect to whole genome sequence typing approaches that are moving into the research arena at an ever-increasing pace. Throughout the paper, we provide exemplar references of these various aspects of MLST. The literature is simply too vast to make this review comprehensive, nevertheless, we have attempted to include enough references in a variety of key areas to introduce the reader to the broad applications and complications of MLST data.

Idioma originalInglés
Páginas (desde-hasta)38-53
Número de páginas16
PublicaciónInfection, Genetics and Evolution
Volumen16
DOI
EstadoPublicada - jun 2013

Áreas temáticas de ASJC Scopus

  • Microbiología
  • Ecología, evolución, comportamiento y sistemática
  • Biología molecular
  • Genética
  • Microbiología (médica)
  • Enfermedades infecciosas

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