Participation of S. Typhimurium cysJIH operon in the H2S-mediated ciprofloxacin resistance in presence of sulfate as sulfur source

Ricardo Álvarez, Jorge Frávega, Paula I. Rodas, Juan A. Fuentes, Daniel Paredes-Sabja, Iván L. Calderón, Fernando Gil

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)

Resumen

H2S production has been proposed as a mechanism to explain bacterial resistance to antibiotics. In this work, we present evidence for the role of the cysJIH operon in resistance to ciprofloxacin mediated by H2S production with different sulfate as the only sulfur source. We found that the products of the cysJIH operon are involved in ciprofloxacin resistance by increasing both, the levels of H2S and reduced thiols apparently counteracting antimicrobial-induced reactive oxygen species (ROS). This protective effect was observed only when bacteria were cultured in the presence of sulfate, but not with cysteine, as the sole sulfur source.

Idioma originalInglés
Páginas (desde-hasta)321-328
Número de páginas8
PublicaciónAntibiotics
Volumen4
N.º3
DOI
EstadoPublicada - 31 jul 2015

Áreas temáticas de ASJC Scopus

  • Microbiología
  • Bioquímica
  • Farmacología, toxicología y ciencias farmacéuticas (todo)
  • Microbiología (médica)
  • Enfermedades infecciosas
  • Farmacología (médica)

Huella

Profundice en los temas de investigación de 'Participation of S. Typhimurium <sub>cys</sub>JIH operon in the H<sub>2</sub>S-mediated ciprofloxacin resistance in presence of sulfate as sulfur source'. En conjunto forman una huella única.

Citar esto