PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications

Cecilia C. Torres, Cristian H. Campos, Carola Diáz, Verónica A. Jiménez, Felipe Vidal, Leonardo Guzmán, Joel B. Alderete

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

26 Citas (Scopus)

Resumen

PAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes.

Idioma originalInglés
Páginas (desde-hasta)164-171
Número de páginas8
PublicaciónMaterials Science and Engineering C
Volumen65
DOI
EstadoPublicada - 1 ago 2016

Áreas temáticas de ASJC Scopus

  • Ciencia de los materiales (todo)
  • Física de la materia condensada
  • Mecánica de materiales
  • Ingeniería mecánica

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