Oxoisoaporphines and aporphines: Versatile molecules with anticancer effects

Esteban Rodríguez-Arce, Patricio Cancino, Manuel Arias-Calderón, Paul Silva-Matus, Marianela Saldías

Resultado de la investigación: Review article

Resumen

Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. One of the most studied sources for anticancer therapy is natural compounds and their derivates, like alkaloids, which are organic molecules containing nitrogen atoms in their structure. Among them, oxoisoaporphine and sampangine compounds are receiving increased attention due to their potential anticancer effects. Boldine has also been tested as an anticancer molecule. Boldine is the primary alkaloid extract from boldo, an endemic tree in Chile. These compounds and their derivatives have unique structural properties that potentially have an anticancer mechanism. Different studies showed that this molecule can target cancer cells through several mechanisms, including reactive oxygen species generation, DNA binding, and telomerase enzyme inhibition. In this review, we summarize the state-of-art research related to oxoisoaporphine, sampangine, and boldine, with emphasis on their structural characteristics and the relationship between structure, activity, methods of extraction or synthesis, and anticancer mechanism. With an effective cancer therapy still lacking, these three compounds are good candidates for new anticancer research.

Idioma originalEnglish
Número de artículo108
PublicaciónMolecules
Volumen25
N.º1
DOI
EstadoPublished - 1 ene 2020

Huella dactilar

Aporphines
Alkaloids
Molecules
alkaloids
Peumus
cancer
molecules
therapy
Neoplasms
Chile
Genomic Instability
Telomerase
Structure-Activity Relationship
Enzyme inhibition
Research
genome
mortality
Reactive Oxygen Species
Nitrogen
nitrogen atoms

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Citar esto

Rodríguez-Arce, E., Cancino, P., Arias-Calderón, M., Silva-Matus, P., & Saldías, M. (2020). Oxoisoaporphines and aporphines: Versatile molecules with anticancer effects. Molecules, 25(1), [108]. https://doi.org/10.3390/molecules25010108
Rodríguez-Arce, Esteban ; Cancino, Patricio ; Arias-Calderón, Manuel ; Silva-Matus, Paul ; Saldías, Marianela. / Oxoisoaporphines and aporphines : Versatile molecules with anticancer effects. En: Molecules. 2020 ; Vol. 25, N.º 1.
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abstract = "Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. One of the most studied sources for anticancer therapy is natural compounds and their derivates, like alkaloids, which are organic molecules containing nitrogen atoms in their structure. Among them, oxoisoaporphine and sampangine compounds are receiving increased attention due to their potential anticancer effects. Boldine has also been tested as an anticancer molecule. Boldine is the primary alkaloid extract from boldo, an endemic tree in Chile. These compounds and their derivatives have unique structural properties that potentially have an anticancer mechanism. Different studies showed that this molecule can target cancer cells through several mechanisms, including reactive oxygen species generation, DNA binding, and telomerase enzyme inhibition. In this review, we summarize the state-of-art research related to oxoisoaporphine, sampangine, and boldine, with emphasis on their structural characteristics and the relationship between structure, activity, methods of extraction or synthesis, and anticancer mechanism. With an effective cancer therapy still lacking, these three compounds are good candidates for new anticancer research.",
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Rodríguez-Arce, E, Cancino, P, Arias-Calderón, M, Silva-Matus, P & Saldías, M 2020, 'Oxoisoaporphines and aporphines: Versatile molecules with anticancer effects', Molecules, vol. 25, n.º 1, 108. https://doi.org/10.3390/molecules25010108

Oxoisoaporphines and aporphines : Versatile molecules with anticancer effects. / Rodríguez-Arce, Esteban; Cancino, Patricio; Arias-Calderón, Manuel; Silva-Matus, Paul; Saldías, Marianela.

En: Molecules, Vol. 25, N.º 1, 108, 01.01.2020.

Resultado de la investigación: Review article

TY - JOUR

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T2 - Versatile molecules with anticancer effects

AU - Rodríguez-Arce, Esteban

AU - Cancino, Patricio

AU - Arias-Calderón, Manuel

AU - Silva-Matus, Paul

AU - Saldías, Marianela

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. One of the most studied sources for anticancer therapy is natural compounds and their derivates, like alkaloids, which are organic molecules containing nitrogen atoms in their structure. Among them, oxoisoaporphine and sampangine compounds are receiving increased attention due to their potential anticancer effects. Boldine has also been tested as an anticancer molecule. Boldine is the primary alkaloid extract from boldo, an endemic tree in Chile. These compounds and their derivatives have unique structural properties that potentially have an anticancer mechanism. Different studies showed that this molecule can target cancer cells through several mechanisms, including reactive oxygen species generation, DNA binding, and telomerase enzyme inhibition. In this review, we summarize the state-of-art research related to oxoisoaporphine, sampangine, and boldine, with emphasis on their structural characteristics and the relationship between structure, activity, methods of extraction or synthesis, and anticancer mechanism. With an effective cancer therapy still lacking, these three compounds are good candidates for new anticancer research.

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Rodríguez-Arce E, Cancino P, Arias-Calderón M, Silva-Matus P, Saldías M. Oxoisoaporphines and aporphines: Versatile molecules with anticancer effects. Molecules. 2020 ene 1;25(1). 108. https://doi.org/10.3390/molecules25010108